Results 101 to 110 of about 19,297 (179)

Substrate‐Dependent Crosslinking by the Cytochrome P450 From Aminopyruvatide Biosynthesis

Angewandte Chemie, Volume 138, Issue 44, 26 October 2026.
Substitutions in the aminopyruvatide precursor peptide altered the C─C linkage formed from a YLY motif by the P450 ApyO to a N─C linkage in a WLY motif. Moreover, constitutional isomers crosslinked by C─C and C─O linkages were formed from YYY or YWY motifs. ABSTRACT Cytochrome P450s catalyze an array of reactions including crosslinking of aromatic side
Chandrashekhar Padhi, Dinh T. Nguyen, Lingyang Zhu, Lide Cha, Jesse W. Wald, Douglas A. Mitchell, Wilfred A. van der Donk   +6 more
wiley   +2 more sources

Recombinant versus native botulinum neurotoxin type A: structural and pharmacodynamic comparison

Acta Crystallographica Section F, Volume 82, Issue 11, Page 391-401, November 2026.
For the first time, the recombinant core botulinum neurotoxin type A (BoNT/A) expressed in Escherichia coli and nicked in vitro is shown to be structurally identical to native BoNT/A from Clostridium botulinum, enabling direct activity comparison between the recombinant product and the native toxin.Botulinum neurotoxins (BoNTs) are highly potent ...
Zongren Yao, Lingyi Xu, Yu Lu, Hui Gong, Xiaoyun Sun, Yaokun Zhao, Jinhuan Chen, Liming Yang, Qingqing Chen, Wu Yang   +9 more
wiley   +1 more source

A nanobiotechnological approach to control non‐persistent aphid‐transmitted plant viruses, based on functionalized virus‐like particles

Annals of Applied Biology, Volume 189, Issue 3, November 2026.
A potyvirus‐derived virus‐like nanoparticle (VLP) interferes in the transmission by aphids of the non‐circulative plant viruses turnip mosaic virus (TuMV, Potyvirus), zucchini yellow mosaic virus (ZYMV, Potyvirus), and cucumber mosaic virus (CMV, Cucumovirus) is also observed. The construct, that consisted of a fusion between a modified TuMV HC‐Pro and
Aranzazu Moreno, Inmaculada Ferriol, Lucia Zurita, Maria Plaza, Rocio Galán‐Cubero, Adriana Urbano‐Bernabé, Alberto Fereres, Fernando Ponz   +7 more
wiley   +1 more source

A Cilia–Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging

Aging Cell, Volume 25, Issue 11, November 2026.
Aging‐associated NAD+ depletion in hypothalamic neurons shortens primary cilia and disrupts CHMP4B trafficking to lysosomes during lysosomal stress, leading to impaired TRPML1–mediated Ca2+ signaling and lysosomal stress responses. Calorie restriction restores hypothalamic NAD+ levels, ciliary structure, and lysosomal homeostasis, thereby improving ...
Se Eun Park, Eun Roh, Jae Woo Park, Seong Jun Kim, So Yeon Jeong, Chae Beom Park, Hyo Sun Lim, Ji Soo Kim, Mun Gyeom Kim, Myeong Ju Kim, Young In Cho, Wontae Jeong, Gil Myoung Kang, Sang‐Yeob Kim, Se Hee Min, Min‐Seon Kim   +15 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Supramolecular Behaviour of Heterochiral Dipeptides With Ile. [PDF]

J Pept Sci
Scarel E, Alletto P, Adorinni S, Fazio F, Pierri G, Tedesco C, Marchesan S.   +6 more
europepmc   +1 more source

High‐variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum

New Phytologist, Volume 252, Issue 3, Page 1215-1231, November 2026.
Functional analysis of predicted interaction‐associated WD40 blades in Fgwd101 and Fgwd048 of Fusarium graminearum. Summary WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein–protein interactions and participates in diverse biological processes.
Soyoung Choi, Nahyun Lee, Jiyeun Park, Hosung Jeon, Sieun Kim, Jung‐Eun Kim, Jiyoung Shin, Heeji Moon, Kyunghun Min, Yejin Choi, Aram Hwangbo, Hun Kim, Gyung Ja Choi, Yin‐Won Lee, Dae‐Geun Song, Hokyoung Son   +15 more
wiley   +1 more source

Rational Design of a Synthetic Galliphore for the Diagnostic Nuclear Imaging and Treatment of Bacterial Infections

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
KO‐NH2 is a synthetic metallophore that preferentially binds Ga3+ over Fe3+ and is recognized by bacterial transporters. Photocrosslinking identifies CirA and Fiu as key uptake proteins in E. coli. KO‐NH2 enables targeted imaging and treatment of E. coli soft tissue infections.
Phuong Nguyen Tran, Axia Marlin, Edith K. Amason, Marie Huynh, Hannah Carlisle, Eszter Boros   +5 more
wiley   +2 more sources

Prepartum Heat Stress Dysregulates Immune Resilience in Postpartum Dairy Cows

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Increasing environmental temperatures pose a major challenge to animal welfare by inducing heat stress and increasing the incidence of disease. Immune resilience is essential for maintaining animal health; however, the mechanisms linking heat stress to immune dysfunction and disease remain unclear.
Arslan Tariq, Masroor Sagheer, Nicholas C. Kertz, Zachary K. Seekford, Maria A. T. de Bari, Gabriela A. Macay, Sriniwas Pandey, Yuting Zhai, Kwangcheol C. Jeong, Geoffrey E. Dahl, John J. Bromfield   +10 more
wiley   +1 more source

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

Angewandte Chemie, Volume 138, Issue 43, 19 October 2026.
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll, Pia Lanvers, Giulia Ravagnan, Kilian Klaus, Olena Nosovska, Ivan Vilotijevic, Jochen Schmid, Hajo Kries   +7 more
wiley   +2 more sources