Results 101 to 110 of about 26,326 (279)

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

The relevance of dipeptides and tripeptides in the bioactivity and taste of dry-cured ham

Food Production, Processing and Nutrition, 2019
Dry-cured ham has been described as a good source of bioactive peptides and taste-active compounds. Some of them are dipeptides and tripeptides that are released in a large amount from different muscle proteins due to the action of exopeptidases during ...
Marta Gallego, Leticia Mora, Fidel Toldrá   +2 more
doaj   +1 more source

Induction and Enhancement of Bacteriocin Production (Review)

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Conventionally, bacteriocins are produced by microorganisms on complex substrates, released as semi‐purified preparations or crude fermentates. These bacteriocin‐containing products often exhibit unsatisfactory purity, low active‐substance content, and high production costs, limiting their commercialization and use. This review aims to analyze
Oksana Knysh, Artur Martynov
wiley   +1 more source

The Separation of Dipeptides by High Performance Liquid Chromatography

, 1986
The separation of underivatized phenylalanine dipeptides by high performance liquid chromatography using a beta-cyclodextrin bonded silica gel column was evaluated. Parameters such as per cent organic modifier, pH, buffer type, and temperature were shown
Ridlon, Cynthia D.
core   +1 more source

Enhanced strategies for cuproptosis‐like death in bacterial infection treatment

BMEMat, EarlyView.
This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang, Bolong Xu, Ruiyuan Zhu, Hengshuo Gui, Tian Xia, Shaokai Liu, Huiyu Liu, Xianwen Wang   +7 more
wiley   +1 more source

Employing Molecular Dynamics Simulations to Explore the Behavior of Diphenylalanine Dipeptides in Graphene-Based Nanocomposite Systems

Inorganics
Utilizing all-atom molecular dynamics simulations, in the current study, we examine how three different graphene-based nanosheets (pristine graphene, graphene oxide and edge-functionalized graphene) impact the self-assembly mechanism of diphenylalanine ...
Elena Markopoulou, Panagiotis Nikolakis, Gregory Savvakis, Anastassia N. Rissanou   +3 more
doaj   +1 more source

Principles of self-assembly of helical pores from dendritic dipeptides

, 2006
The self-assembly of the dendritic dipeptides (4-3,4-3,5)nG2-CH -Boc-L-Tyr-L-Ala-OMe and their achiral dendritic alcohol (4-3,4-3,5)nG2-CHOH precursors, both with n = 1-16, where n represents the number of methylenic units in the alkyl groups of the ...
Ilies, Monica, P. A. Heiney, Peterca, Mihai, M. J. Sienkowska, Heiney, Paul A., Nummelin, Sami, M. Peterca, V. Percec, Dulcey, Andrés E., S. Nummelin, Percec, Virgil, Sienkowska, Monika J., A. E. Dulcey, M. Ilies   +13 more
core   +1 more source

Biomaterials for modulating cellular responses of endogenous tendon stem/progenitor cells: A promising avenue for tendon regeneration

BMEMat, EarlyView.
This review comprehensively summarizes emerging biomaterial‐based strategies and underlying mechanisms for modulating endogenous tendon stem/progenitor cells (TSPCs). It offers the most recent insights into TSPC physiology and potential applications of tissue engineering and regenerative medicine in tendons.
Zeyu Zhu, Renwang Sheng, Mumin Cao, Ludvig J. Backman, Yucheng Gao, Hao Wang, Cheng Zhang, Jialin Chen, Wei Zhang, Yunfeng Rui   +9 more
wiley   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Localized Prostate Cancer Therapy: Tumor Microenvironment‐Activated Spermine Hydrogel With Real‐Time Autonomous Fluorescence Sensing

Chemistry – A European Journal, EarlyView.
First tumor microenvironment (TME)‐responsive spermine‐loaded hydrogel with autonomous sensing for advanced local therapy of prostate cancer (PCa) is developed. Spermine can be released from the hydrogel to kill the prostate cancer cells specifically under acidic TME.
Ho‐Fai Chau, Wing‐Sze Tam, Gengguo Deng, Yik Hoi Yeung, Christine Yim Ping Wong, Ka Lo Cheng, Zhengxiao Liu, Lijia Yao, Yi Wang, Angelo H. All, Chi‐Fai Ng, Jinming Di, Ka‐Leung Wong   +12 more
wiley   +1 more source