Results 111 to 120 of about 38,805 (284)

APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy. [PDF]

, 2019
Tumor-associated neo-antigens are mutated peptides that allow the immune system to recognize the affected cell as foreign. Cells carrying excessive mutation load often develop mechanisms of tolerance.
Boichard, Amélie, Frampton, Garrett M, Goodman, Aaron, Kurzrock, Razelle, Lippman, Scott, Pham, Timothy V, Tamayo, Pablo, Tsigelny, Igor F, Yeerna, Huwate   +8 more
core  

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

The relevance of dipeptides and tripeptides in the bioactivity and taste of dry-cured ham

Food Production, Processing and Nutrition, 2019
Dry-cured ham has been described as a good source of bioactive peptides and taste-active compounds. Some of them are dipeptides and tripeptides that are released in a large amount from different muscle proteins due to the action of exopeptidases during ...
Marta Gallego, Leticia Mora, Fidel Toldrá   +2 more
doaj   +1 more source

Design and Synthesis of Lactose‐Derived Ligands and Their Application in Asymmetric Friedel–Crafts Alkylation

European Journal of Organic Chemistry, EarlyView.
This work describes the synthesis of lactose‐ and glucose‐derived chiral ligands and their application in the catalytic enantioselective Friedel–Crafts alkylation of indole with a series of trans‐β‐nitrostyrenes. The optimal ligand was an acetate protected, lactose‐derived pyridyl imine and its zinc complex afforded ees up to 93% and yields up to 93 ...
Sandra Bulawa, Julia Bruno‐Colmenarez, Patrick J. Guiry   +2 more
wiley   +1 more source

Hofmann Degradation of Asparagine and Glutamine as an Efficient Approach for the Synthesis of Derivatized Lysine Homologs

European Journal of Organic Chemistry, EarlyView.
A practical and scalable route to C1 and C2 lysine homologs has been developed using Hofmann degradation of N‐protected L‐asparagine and L‐glutamine as the key step. These short‐tether scaffolds enable efficient synthesis of diverse Fmoc‐protected noncanonical amino acids (ncAAs) bearing donor, acceptor, redox‐active, and fluorescent residues.
Adelaide R. Mashweu, François J. De Beer, Jolien Bertouille, Steven Ballet, Charlotte Martin, Ulrich Hennecke, Charlene Marais, Vladimir A. Azov   +7 more
wiley   +1 more source

Almond (Amygdalus communis L.) Peptides Improve Scopolamine‐Induced Learning and Memory Impairment in Mice

Food Safety and Health, EarlyView.
Figure Schematic showing the improvement of almond peptides on learning and memory impairment induced by scopolamine in mice. Almond peptides (APs) could improve the learning and memory in scopolamine‐induced mice by maintaining cholinergic system homeostasis and regulating Nrf2/Keap1 signaling pathway, via activating the Nrf2 transcription factor and ...
Xin Shang, Wenjing Gao, Caiyun Zhao, Bin Li, Jintian Guo, Jingteng Wang, Minwei Zhang, Yinghua Fu   +7 more
wiley   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

In silico prediction and structural characterization of multifunctional bioactive peptides released from olive proteins

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Olive (Olea europaea L.) byproducts, such as seeds and leaves, are abundant agro‐industrial residues and represent underexplored protein sources with potential health relevance. However, the repertoire of bioactive peptides that may be released from olive proteins during gastrointestinal digestion remains poorly characterized.
Teresa Gonzalez‐de la Rosa, Luna Barrera‐Chamorro, Africa Fernandez‐Prior, Elvira Marquez‐Paradas, Maria Torrecillas‐Lopez, Fernando Rivero‐Pino, Sergio Montserrat‐de la Paz   +6 more
wiley   +1 more source