Results 121 to 130 of about 26,326 (279)

Two mechanisms of membrane digestion: enzymatic-transport ensemble exists for oligopeptides as well

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011
Aim of investigation. To determine, which mechanism of dipeptide transport is realized under experimental conditions: PEPT1-mediated transport of the intact dipeptides or transport of the amino acid formed as a result of membrane hydrolysis of dipeptides
S. T. Metelsky, V. T. Ivashkin
doaj  

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

Use of a Bacteriophage Lysin to Control Axillary Malodor

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Axillary malodor is primarily caused by bacteria, particularly Staphylococcus hominis, which metabolize apocrine secretions into volatile compounds. Traditional deodorants contain antiseptics that can disrupt the skin microbiome and cause irritation. Alternative methods of odor control are being sought but so far without success. We
Maurice A. M. van Steensel, Fabian Hia, Mei Zhen Beh, Boon Chong Goh   +3 more
wiley   +1 more source

Exploring a Ugi‐Mediated Polymerization‐Induced Self‐Assembly Approach to Peptoid Particles

Macromolecular Rapid Communications, EarlyView.
Ugi‐mediated polymerization‐induced self‐assembly (U‐PISA) enables the one‐pot synthesis of PEG‐stabilized polypeptoid nanoparticles under mild aqueous conditions. By tuning PEG molar mass and feed composition, tunable spherical and worm‐like nano‐objects are obtained.
Thi Phuong Thu Nguyen, Maria Cristina Molaro, Hao‐Ning Tien, Lei Lei, Pierre Stiernet, Clemence Le Coeur, Federica Sodano, Antoine Debuigne, Benoit Couturaud   +8 more
wiley   +1 more source

C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers

Nuclear import receptors (NIRs) not only transport RNA-binding proteins (RBPs) but also modify phase transitions of RBPs by recognizing nuclear localization signals (NLSs).
Morikawa, Naritaka, Saio, Tomohide, Mori, Eiichiro, 28899, 28897, Shinkai, Yoichi, Shoji, Osami, 28898, Mannen, Taro, Nagata, Riko, Uehara, Takeru, Yoshizawa, Takuya, 28895, 28896, Kiriyama, Takao, Wiriyasermkul, Pattama, Toma-Fukai, Sachiko, 28907, 28908, 28905, 28906, 28909, Kodera, Noriyuki, 28900, Hibino, Masaki, Taguchi, Hideki, 28903, Morishima, Ken, 28904, Fujiwara, Ayano, 28901, Ishimori, Koichiro, 28902, Sugie, Kazuma, Oda, Takashi, Aiba, Yuichiro, 28918, 28919, 28916, 28917, Niwa, Tatsuya, 28910, 28911, Iguchi, Naohiko, 28914, 28915, 28912, Matsubayashi, Masaya, 28913, Nakanishi, Mari, Matsumura, Hiroyoshi, Sugiyama, Masaaki, Nagamori, Shushi, 28927, 28928, Shiota, Tomo, Sato, Mamoru, 28921, 28922, Kikuchi, Sotaro, 28920, 28925, 28926, 28923, 28924, Nanaura, Hitoki, Kawamukai, Honoka, Inoue, Rintaro   +67 more
core  

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Dipeptides in clinical nutrition [PDF]

Proceedings of the Nutrition Society, 1990
P, Fürst, S, Albers, P, Stehle
openaire   +2 more sources

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source