Results 171 to 180 of about 38,805 (284)

XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease

MedComm, Volume 7, Issue 5, May 2026.
XIAP deficiency leads to impaired colonic tuft cells development and JAK–‐STAT pathway hyperactivation in CD patients and mice. Mechanically, XIAP regulates tuft cells development through Wnt–‐TLE4/TCF–‐ASCL2 signaling. Tuft cells deficiency predisposes XIAP‑‐deficient CD patients or Xiap−/−‐/‐ mice to hazardous microbial effects, driving colonic ...
Rongli Fang, Wei Wang, Li Zhang, Jiwei Huang, Lei Huang, Huibo Wu, Yuyin Qi, Lili Li, Liren Tan, Min Zhang, Jianheng Zhu, Xiang Peng, Kanghua Zhong, Ming Zou, Xi Yang, Qiuhua Wang, Changjun Nie, Chaorui Tang, Ning Tang, Lanlan Geng, Hanhan Chen, James E. Vince, Hirokazu Kanegane, Xiaodong Zhao, Huifang Xian, Wenhao Zhou, Min Zhi, Yuxia Zhang, Zhanghua Chen   +28 more
wiley   +1 more source

Substrate selectivity of human histidine methyltransferase METTL9

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Methylation of histidine residues in zinc transporters by histidine methyltransferase METTL9 plays an important role in modulating their metal‐binding properties. Here, we report synthetic, enzymatic, and computational studies on human METTL9‐catalyzed Nπ‐methylation of His375 in zinc transporter SLC39A5‐derived peptides in which the histidine
Sadaf Ahmad, Laust Moesgaard, Christian W. Tornøe, Paulina Emmel, Klaudia Slusarczyk, Jakub Drozak, Jacob Kongsted, Jasmin Mecinović   +7 more
wiley   +1 more source

Integrated In Silico - In Vitro Study Investigating Dipeptides as Chorismate Synthase Modulators: Spotlight on Its Mechanism of Action. [PDF]

Glob Chall
Pedroni L, Fuchs K, Galaverna G, Macheroux P, Dellafiora L.   +4 more
europepmc   +1 more source

Fluctuating β‐Sheet Secondary Structure in DS119 Explains the Small Effects of Backbone N‐Amination on Thermal Stability

Journal of Peptide Science, Volume 32, Issue 5, May 2026.
Residues with backbone N‐amination have been introduced into a region of parallel β‐sheet secondary structure. Contrary to predictions, the N‐amination of Trp9 or Phe33 did not give an increase in the thermal stability of DS119. MD simulations suggest this is due to the highly fluctuating nature of the β‐sheet region. ABSTRACT The miniprotein DS119 has
Yushi Qiao, Syrah K. Starnes, Jožica Dolenc, Juan R. Del Valle, Lorna J. Smith   +4 more
wiley   +1 more source

The Effect of Serum Carnosinase on the Tissue Distribution of Imidazole Dipeptides After Their Oral Administration in Golden Hamsters. [PDF]

Nutrients
Shiotani S, Kawashima T, Takahashi C, Sakano T, Kuramoto A, Yanai N.   +5 more
europepmc   +1 more source

Shear‐Induced Anisotropic Supramolecular Gel Noodles for Improved Cell Guidance in Polarized Tissue Engineering

Small, Volume 22, Issue 26, 8 May 2026.
A simple two‐stage extrusion aligns supramolecular fibrils into 1D gel noodles. The residual pressure in the viscous pre‐gel drives the formation of a thin filament that is locked by Ca2+ cross‐linker into a highly anisotropic segment. The aligned noodles show enhanced tensile strength and guide myoblast elongation along the fiber, mimicking aligned ...
Dipankar Ghosh, Matthew Walker, Lauren Matthews, Charlie Patterson, Oana Dobre, Massimo Vassalli, Dave J. Adams   +6 more
wiley   +1 more source

Myocardial protection by acidic amino acids and natural dipeptides: potential for an underused resource. [PDF]

Amino Acids
King N.
europepmc   +1 more source

Imidazol dipeptides

Nippon Shokuhin Kagaku Kogaku Kaishi, 2014
openaire   +2 more sources

Optimal 1TEL–target protein linker character is target protein‐dependent

Acta Crystallographica Section D, Volume 82, Issue 5, Page 516-532, May 2026.
In this study, we examine the effect of short to medium‐length flexible, semi‐flexible and rigid linkers on the crystallization of a DARPin or the TNK1 UBA domain fused to the 1TEL protein crystallization chaperone, demonstrating that while rigid linkers can impair crystallization and reduce diffraction quality, the ideal linker character remains ...
Maria J. Pedroza Romo, Alihikaua Keliiliki, Jacob C. Averett, Joseph F. Gonzalez, Ethan Noakes, Elijah W. Wilson, Conrad Smith, Blake Averett, Dalton Hansen, Riley Nickles, Miles Bradford, Sara Soleimani, Tobin Smith, Supeshala Nawarathnage, Prasadika Samarwickrama, Ariel Kelsch, Derick Bunn, Cameron Stewart, Wisdom Abiodun, Evan Tsubaki, Seth Brown, Tzanko I. Doukov, James D. Moody   +22 more
wiley   +1 more source

Correction: Differential modulation of tomato root exudates by <i>Streptomyces</i> strains underlies contrasting control of <i>Fusarium oxysporum</i> f. sp. <i>lycopersici</i>. [PDF]

Front Plant Sci
Frontiers Production Office .
europepmc   +1 more source