Results 21 to 30 of about 38,805 (284)

The New Dipeptide TSPO Ligands: Design, Synthesis and Structure–Anxiolytic Activity Relationship

Molecules, 2020
The translocator protein (TSPO, 18 kDa) plays an important role in the synthesis of neurosteroids by promoting the transport of cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step in neurosteroidogenesis ...
Tatiana A. Gudasheva, Olga A. Deeva, Andrey S. Pantileev, Grigory V. Mokrov, Inna V. Rybina, Milada A. Yarkova, Sergei B. Seredenin   +6 more
doaj   +1 more source

Amino acids induce peptide uptake via accelerated degradation of CUP9, the transcriptional repressor of the PTR2 peptide transporter [PDF]

, 2008
Multiple pathways link expression of PTR2, the transporter of di- and tripeptides in the yeast Saccharomyces cerevisiae, to the availability and quality of nitrogen sources.
Abdel-Sater, Abdel-Sater, Alagramam, Andréasson, Andréasson, Bachmair, Bernard, Boban, Boles, Byrd, Cai, Cai, Ditzel, Du, Fosberg, Frommer, Ghislain, Godard, Graciet, Holsbeeks, Homann, Hou, Hu, Hu, Hu, Inobe, Island, Johnson, Jorgensen, Klasson, Kwon, Kwon, Laney, Lee, Liu, Malavé, Mogk, Nielsen, Rao, Roosen, Sasaki, Schneider, Sikorski, Spielewoy, Suzuki, Tasaki, Tasaki, Tasaki, Turner, Turner, Varshavsky, Varshavsky, Varshavsky, Wiles, Wu, Xia, Xiao, Xie, Zenker   +58 more
core   +3 more sources

Dipeptide Absorption in Cystinuria [PDF]

Clinical Science, 1970
Absorption of a dipeptide and its constituent amino-acids has been studied by a perfusion technique in a patient with cystinuria and in a normal subject. Though the cystinuric patient was unable to absorb the dibasic amino-acid lysine in its free form, the dipeptide glycyl-L-lysine was well absorbed.
M D, Hellier, D, Perrett, C D, Holdsworth   +2 more
openaire   +3 more sources

Crystal structure of the N-benzyloxycarbonyl-Alanyl-Phenylalanyl-methyl ester: the importance of the H-bonding pattern [PDF]

, 2011
Large crystals of the methyl ester of the N-a-benzyloxycarbonyl protected Ala-Phe dipeptide (Z-AF-OMe) were obtained after the very slow evaporation of a solution of the corresponding carboxylic acid (Z-AF-OH) in methanol containing an excess of HCl. The
Alfonso, Ignacio, Bolte, Michael, Burguete, M. Isabel, Luis, Santiago V.   +3 more
core   +2 more sources

Dipeptide absorption in man [PDF]

Gut, 1972
A quantitative perfusion method has been used to study intestinal absorption of two dipeptides-glycyl-glycine and glycyl-l-alanine-in normal subjects. In each case, the constituent amino acids were absorbed faster when presented as dipeptides than as free amino acids, suggesting intact dipeptide transport. During absorption constituent amino acids were
M D, Hellier, C D, Holdsworth, I, McColl, D, Perrett   +3 more
openaire   +2 more sources

Nearest-Neighbor Interactions and Their Influence on the Structural Aspects of Dipeptides

Biochemistry Research International, 2013
In this theoretical study, the role of the side chain moiety of C-terminal residue in influencing the structural and molecular properties of dipeptides is analyzed by considering a series of seven dipeptides.
Gunajyoti Das, Shilpi Mandal
doaj   +1 more source

Synthesis and evaluation of cerebroprotective activity of novel 6,7-dimethoxyquinazolin-4(3H)-one derivatives containing residues of amino acids and dipeptides

Chimica Techno Acta, 2022
Neurodegenerative processes of the central nervous system are an important socially significant problem of modern society. They cause many diseases, such as Alzheimer's disease and cerebral ischemia, which significantly reduce the quality of human life ...
Alexey S. Chiriapkin, Ivan P. Kodonidi, Dmitry I. Pozdnyakov   +2 more
doaj   +1 more source

Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway [PDF]

, 2008
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. These residues are recognized by E3 ubiquitin ligases called N-recognins. Ubr1 is the N-recognin of the yeast Saccharomyces cerevisiae.
A. Varshavsky, Abdel-Sater, Andreasson, C.-S. Hwang, Doble, Dornan, Forsberg, He, Homann, Hunter, Knippschild, Kwon, Lochhead, Poulsen, Ravid, Santangelo, Sasaki, Tasaki, Varshavsky, Varshavsky, Xie, Zenker   +21 more
core   +3 more sources

Synthesis and binding studies of two new macrocyclic receptors for the stereoselective recognition of dipeptides

Beilstein Journal of Organic Chemistry, 2010
We present here the design, synthesis, and analysis of a series of receptors for peptide ligands inspired by the hydrogen-bonding pattern of protein β-sheets.
Ana Maria Castilla, M. Morgan Conn, Pablo Ballester   +2 more
doaj   +1 more source

Characterization of Umami Dry-Cured Ham-Derived Dipeptide Interaction with Metabotropic Glutamate Receptor (mGluR) by Molecular Docking Simulation

Applied Sciences, 2021
Dry-cured ham-derived dipeptides, generated along a dry-curing process, are of high importance since they play a role in flavor development of dry-cured ham.
Alejandro Heres, Fidel Toldrá, Leticia Mora   +2 more
doaj   +1 more source