Results 41 to 50 of about 26,326 (279)

Schistosome dipeptide of love

Trends in Parasitology, 2022
The female schistosome's dependence on the male to reach sexual maturity has puzzled scientists for decades. Using various molecular techniques, Chen et al. dissect the synthesis pathway of the β-alanyl-tryptamine dipeptide (BATT), emitted by the male into its environment, which induces sexual maturation and egg-laying in the female.
Yohann Le Govic, Jérôme Boissier, Nicolas Papon   +2 more
openaire   +4 more sources

Characterization of γ-glutamyl cysteine ligases from Limosilactobacillus reuteri producing kokumi-active γ-glutamyl dipeptides

, 2021
γ-Glutamyl cysteine ligases (Gcls) catalyze the first step of glutathione synthesis in prokaryotes and many eukaryotes. This study aimed to determine the biochemical properties of three different Gcls from strains of Limosilactobacillus reuteri that ...
Gänzle, Michael G., Xie, Jin
core   +1 more source

Supramolecular Behaviour of Heterochiral Dipeptides With Ile. [PDF]

J Pept Sci
This study describes the supramolecular behaviour and gelation of heterochiral, aliphatic dipeptides d‐Ile‐l‐Xaa (Xaa = Ala, Val, Leu or Ile) in various solvents and buffered water at neutral pH. Metastable gels rapidly crystallised. X‐ray diffraction analysis was conducted to unveil the dipeptides' packing modes in amphipathic layers.
Scarel E, Alletto P, Adorinni S, Fazio F, Pierri G, Tedesco C, Marchesan S.   +6 more
europepmc   +2 more sources

Lewis‐Acid‐Catalyzed Synthesis of Amadori and Heyns Dipeptides

, 2020
Amadori and Heyns reactions are milestone reactions of carbohydrate chemistry. There have been little efforts in transforming these rearrangement reactions to useful catalytic tools.
Debasree, Chanda, Nanishankar, V. Harohally, Nanishankar V. Harohally, Venkataswamy, Gangothri M., Gangothri M. Venkataswamy, Debasree Chanda   +5 more
core   +1 more source

Carnosine in the context of histidine-containing dipeptides

, 2015
Even though histidine constitutes one of the least abundant residues, it often plays key biochemical roles in protein environments due to the peculiar reactivity of the imidazole ring that characterizes its side chain.
G. Vistoli, Giulio Vistoli
core   +1 more source

Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications

Angewandte Chemie, EarlyView.
Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika, Matthew Murray, Guillermo Palop, Lee‐Ann J. Keane, Patrick McArdle, Nicholas D. J. Yates, Christopher D. Spicer, Alison Parkin, Martin A. Fascione, Eddie L. Myers   +9 more
wiley   +2 more sources

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie, EarlyView.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro [PDF]

Journal of the American Chemical Society, 2015
Plasmids containing 23S rRNA randomized at positions 2057-2063 and 2502-2507 were introduced into Escherichia coli, affording a library of clones which produced modified ribosomes in addition to the pre-existing wild-type ribosomes. These clones were screened with a derivative of puromycin, a natural product which acts as an analogue of the 3'-end of ...
Rumit, Maini, Larisa M, Dedkova, Rakesh, Paul, Manikandadas M, Madathil, Sandipan Roy, Chowdhury, Shengxi, Chen, Sidney M, Hecht   +6 more
openaire   +2 more sources

Seryl Dipeptides

, 2012
This article describes the stereo- and regioselectivity of the deoxofluorination of N-terminal dipeptides bearing a serine residue to generate, after rearrangement, a-fluoro-beta-amine-terminated dipeptides.
Daniel L. Smith, David O'Hagan, O'Hagan, David, Alexandra M. Z. Slawin, Smith, Daniel L., Slawin, Alexandra M. Z.   +5 more
core   +1 more source