Results 51 to 60 of about 18,468 (228)

Muscle histidine-containing dipeptides are elevated by glucose intolerance in both rodents and men. [PDF]

PLoS ONE, 2015
Muscle carnosine and its methylated form anserine are histidine-containing dipeptides. Both dipeptides have the ability to quench reactive carbonyl species and previous studies have shown that endogenous tissue levels are decreased in chronic diseases ...
Sanne Stegen, Inge Everaert, Louise Deldicque, Silvia Vallova, Barbora de Courten, Barbara Ukropcova, Jozef Ukropec, Wim Derave   +7 more
doaj   +1 more source

Machine Learning Interatomic Potentials for Energy Materials: Architectures, Training Strategies, and Applications

Advanced Energy Materials, EarlyView.
Machine learning interatomic potentials bridge quantum accuracy and computational efficiency for materials discovery. Architectures from Gaussian process regression to equivariant graph neural networks, training strategies including active learning and foundation models, and applications in solid‐state electrolytes, batteries, electrocatalysts ...
In Kee Park, Saeed Pourasad, Jinhong Mun, Arunkumar Chitteth Rajan, Tae Hyeon Park, Anand Rohit, Mohammad Zafari, Tan‐Lien Pham, Eunjae Jung, Bonseung Koo, Miran Ha, Gi Beom Sim, Hyun Gyu Park, Won Woong Choi, Kwanghyeon Jo, Soohaeng Yoo Willow, David ChangMo Yang, Chang Woo Myung, Geunsik Lee, Kwang S. Kim   +19 more
wiley   +1 more source

Nematophin, an Antimicrobial Dipeptide Compound From Xenorhabdus nematophila YL001 as a Potent Biopesticide for Rhizoctonia solani Control

Frontiers in Microbiology, 2019
This study was conducted to purify and identify metabolites of antimicrobial activity against phytopathogens from Xenorhabdus nematophila YL001. Three dipeptide compounds were purified from its cell-free cultural broth and identified as (±)-nematophin ...
Shujing Zhang, Qi Liu, Yunfei Han, Jinghua Han, Zhiqiang Yan, Yonghong Wang, Xing Zhang   +6 more
doaj   +1 more source

Inhibition of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase enzyme by dipeptides identified in dry-cured ham

Food Production, Processing and Nutrition, 2021
High cholesterolemia is a key risk factor for the development of cardiovascular diseases, which are the main cause of mortality in developed countries.
Alejandro Heres, Leticia Mora, Fidel Toldrá   +2 more
doaj   +1 more source

Peptide Transporter 1‐Mediated Dipeptide Transport Promotes Hepatocellular Carcinoma Metastasis by Activating MAP4K4/G3BP2 Signaling Axis

Advanced Science
Cancer metastasis is the leading cause of mortality in patients with hepatocellular carcinoma (HCC). To meet the rapid malignant growth and transformation, tumor cells dramatically increase the consumption of nutrients, such as amino acids.
Feifeng Song, Zhentao Zhang, Weifeng Liu, Tong Xu, Xiaoping Hu, Qiyue Wang, Wanli Zhang, Luqi Ge, Chengwu Zhang, Qing Hu, Hui Qin, Song Zhang, Xinxin Ren, Weijiao Fan, Yiwen Zhang, Ping Huang   +15 more
doaj   +1 more source

Peptidthioester und Peptidtriazolderivate durch Duale Modifikation von Peptidthiosulfonaten auf dem Harz

Angewandte Chemie, EarlyView.
Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Active site remodelling of a cyclodipeptide synthase redefines substrate scope

Communications Chemistry, 2022
Cyclodipeptide synthases (CDPSs) generate a wide range of cyclic dipeptides using aminoacylated tRNAs as substrates, however the substrate selection mechanism is not yet known.
Emmajay Sutherland, Christopher John Harding, Clarissa Melo Czekster   +2 more
doaj   +1 more source

The Pharmacogenetic Footprint of ACE Inhibition: A Population-Based Metabolomics Study. [PDF]

PLoS ONE, 2016
Angiotensin-I-converting enzyme (ACE) inhibitors are an important class of antihypertensives whose action on the human organism is still not fully understood.
Elisabeth Altmaier, Cristina Menni, Margit Heier, Christa Meisinger, Barbara Thorand, Jan Quell, Michael Kobl, Werner Römisch-Margl, Ana M Valdes, Massimo Mangino, Melanie Waldenberger, Konstantin Strauch, Thomas Illig, Jerzy Adamski, Tim Spector, Christian Gieger, Karsten Suhre, Gabi Kastenmüller   +17 more
doaj   +1 more source

Peptide Thioester and Triazole Derivatives Through On‐Resin Dual‐Modification of Peptide Thiosulfonates

Angewandte Chemie International Edition, EarlyView.
An on‐resin dual‐modification strategy for peptides is presented, comprising S‐alkynylation of peptide thiosulfonates and regioselective iridium‐catalyzed azide–thioalkyne cycloaddition. This method reliably provides access to peptides with intricate non‐canonical modifications, being compatible with complex peptides, alkynes and azides.
Marius Werner, Agnes Bergmann, Chenxi Liu, Mira Behnam, Christian Klein, Franziska Thomas   +5 more
wiley   +1 more source

Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis

Metabolites, 2020
As the physical properties and functionality of dipeptides differ from those of amino acids, they have attracted attention in metabolomics; however, their functions in vivo have not been clarified in detail.
Hitoshi Ozawa, Akiyoshi Hirayama, Futaba Shoji, Midori Maruyama, Kumi Suzuki, Hisami Yamanaka-Okumura, Hiroshi Tatano, Yuji Morine, Tomoyoshi Soga, Mitsuo Shimada, Masaru Tomita   +10 more
doaj   +1 more source