Results 71 to 80 of about 26,326 (279)
Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic
Angewandte Chemie, EarlyView.To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll +7 more
wiley +2 more sources
Evaluating the Reduced Hydrophobic Taste Sensor Response of Dipeptides by Theasinensin A by Using NMR and Quantum Mechanical Analyses. [PDF]
PLoS ONE, 2016 The current study demonstrated that theasinensin A (TSA) had a potential to form the complex with hydrophobic Trp-containing dipeptides, and to reduce their membrane potential by artificial-lipid membrane taste sensor.
Jian Guo +8 more
doaj +1 more source
Association of DPP4 with esophageal stricture progression and the Hippo‐YAP pathway
Animal Models and Experimental Medicine, EarlyView.This study establishes a comprehensive translational platform for esophageal stricture (ES) research by integrating a novel rat model with clinically relevant porcine validation. This study identifies DPP4 as a gene of interest associated with ES following endoscopic submucosal dissection, demonstrating that prophylactic DPP4 inhibition attenuates ...
Rui Wu +5 more
wiley +1 more source
Frontiers in Microbiology, 2019 This study was conducted to purify and identify metabolites of antimicrobial activity against phytopathogens from Xenorhabdus nematophila YL001. Three dipeptide compounds were purified from its cell-free cultural broth and identified as (±)-nematophin ...
Shujing Zhang +6 more
doaj +1 more source
A Minimalistic Hydrolase Based on Co-Assembled Cyclic Dipeptides [PDF]
, 2019 This paper describes minimalistic cyclic dipeptides acting as esterase-mimicks in a self-assembled hydrogel state. It demonstrates that cyclic dipeptides could have acted as enzyme-precursors on a primordial earth and hence be important for abiogenesis.
Boris Nachtsheim (6992930) +3 more
core +1 more source
Food Production, Processing and Nutrition, 2021 High cholesterolemia is a key risk factor for the development of cardiovascular diseases, which are the main cause of mortality in developed countries.
Alejandro Heres +2 more
doaj +1 more source
Advanced ScienceCancer metastasis is the leading cause of mortality in patients with hepatocellular carcinoma (HCC). To meet the rapid malignant growth and transformation, tumor cells dramatically increase the consumption of nutrients, such as amino acids.
Feifeng Song +15 more
doaj +1 more source
Active site remodelling of a cyclodipeptide synthase redefines substrate scope
Communications Chemistry, 2022 Cyclodipeptide synthases (CDPSs) generate a wide range of cyclic dipeptides using aminoacylated tRNAs as substrates, however the substrate selection mechanism is not yet known.
Emmajay Sutherland +2 more
doaj +1 more source
, 2015 Getting inspiration from nature and further developing functional architectures provides an effective way to design innovative materials and systems. Among bio-inspired materials, dipeptides and its self-assembled architectures with functionalities have ...
Chen, Chengjun +3 more
core +1 more source
Angewandte Chemie, EarlyView.Es wird eine Strategie zur dualen Modifikation von Peptiden auf der Festphase vorgestellt, die die S‐Alkinylierung von Peptidthiosulfonaten und eine regioselektive, iridiumkatalysierte Azid‐Thioalkin‐Zykloaddition umfasst. Dieses Verfahren ermöglicht zuverlässig den Zugang zu Peptiden mit komplexen, nicht‐kanonischen Modifikationen und ist mit ...
Marius Werner +5 more
wiley +1 more source