Results 31 to 40 of about 38,805 (284)

CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. [PDF]

, 2018
Hexanucleotide-repeat expansions in the C9ORF72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia (c9ALS/FTD).
A Berson, A Jovičić, AA Dominguez, Aaron D. Gitler, AC Elden, AD Gitler, AD Gitler, AD Gitler, AE Renton, AM Jablonski, Amy Li, Ana Jovičić, AS Ng, BD Freibaum, C Sidrauski, C Sidrauski, C. Kimberly Tsui, D Ron, David W. Morgens, DW Morgens, DW Morgens, E Yeger-Lotem, EM Lynes, EY Son, FB Gao, Gregor Bieri, H Koike-Yusa, HJ Kim, HJ Kim, I Kwon, IR Mackenzie, IR Mackenzie, J Couthouis, J Joung, James Ousey, JC Christianson, JG Wideman, JP Taylor, Julien Couthouis, Justin K. Ichida, K Kanekura, K Mori, K Zhang, KH Lee, KM Green, KY Shi, L Ellgaard, L Huang, LA Becker, LA Gilbert, LA Gilbert, M Armakola, M DeJesus-Hernandez, M Neumann, M Prudencio, MA Horlbeck, Marc Tessier-Lavigne, MC Jonikas, MH Schludi, MI Love, Michael C. Bassik, Michael S. Haney, NF Liachko, Nicholas J. Kramer, Nicholas T. Hertz, O Shalem, OM Peters, PE Ash, Q Zhou, R Dafinca, R Lopez-Gonzalez, R Seijffers, RJ Platt, RM Deans, Rosanna Ma, S Boeynaems, S Boeynaems, S Ju, S Konermann, S Mizielinska, S Treusch, SC Ling, SJ Zhang, T Wang, T Westergard, T Zu, TF Gendron, W Cheng, X Wen, Y Lin, Y Zhou, Yingxiao Shi, YJ Zhang, YS Davidson, Z Shevtsova, Z Sun   +95 more
core   +1 more source

Modeling of Self-Assembled Peptide Nanotubes and Determination of Their Chirality Sign Based on Dipole Moment Calculations

Nanomaterials, 2021
The chirality quantification is of great importance in structural biology, where the differences in proteins twisting can provide essentially different physiological effects.
Vladimir Bystrov, Alla Sidorova, Aleksey Lutsenko, Denis Shpigun, Ekaterina Malyshko, Alla Nuraeva, Pavel Zelenovskiy, Svitlana Kopyl, Andrei Kholkin   +8 more
doaj   +1 more source

Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two apparently distinct neurodegenerative diseases, the former characterized by selective loss of motor neurons in the brain and spinal cord and the latter characterized by ...
Pasinelli, Piera, Trotti, Davide, Wen, Xinmei, Westergard, Thomas   +3 more
core   +2 more sources

L-Glutamine peptides as a means of accelerated rehydration under intense physical activity in athletes

Спортивная медицина: наука и практика, 2020
This review is devoted to the theory and practice of the use of glutamine dipeptides in sports. The pathway of L-Glutamine dipeptides is described from the moment of oral intake and entering the intestine to inclusion in intracellular metabolic processes
T. Pushkina, T. Popova, A. Zholinsky, A. Dmitriev, E. Tokaev, M. Klyuchnikov, A. Shestopalov   +6 more
doaj   +1 more source

Self-Assembly of the Dipeptide L-Alanyl-L-Phenylalanine under the Action of Methanol Vapor with the Formation of Micro- and Nanostructures

Учёные записки Казанского университета: Серия Естественные науки, 2023
The mechanism of self-assembly by short-chain peptides (oligopeptides) – the process by which their molecules spontaneously form an ordered structure – has received much attention recently.
A. S. Morozova, E. O. Kudryavtseva, S. A. Ziganshina, M. A. Ziganshin, A. A. Bukharaev   +4 more
doaj   +1 more source

Recent advances in experimental techniques to probe fast excited-state dynamics in biological molecules in the gas phase : dynamics in nucleotides, amino acids and beyond [PDF]

, 2013
In many chemical reactions, an activation barrier must be overcome before a chemical transformation can occur. As such, understanding the behaviour of molecules in energetically excited states is critical to understanding the chemical changes that these ...
Hadden DJ, Lodish H, Rossle S, Satzger H, Scoles G, Vastola FJ, Yang X   +6 more
core   +1 more source

Analysis of dipeptides in Chinese liquors based on dansylation combined with liquid chromatography–mass spectrometry

Food Chemistry: X, 2023
Dipeptides have been shown to be an important taste substance in alcoholic beverages. However, the characterization of dipeptides in Chinese liquors was poor.
Yubo Yang, Xin Lu, Fan Yang, Zhen Jia, Xiaoyu Xie, Nian Cao, Di Yu, Fujian Zheng, Xinyu Liu, Li Wang, Guowang Xu   +10 more
doaj   +1 more source

Bivalent Inhibitor of the N-end Rule Pathway [PDF]

, 1999
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Ubr1p, the recognition (E3) component of the Saccharomyces cerevisiae N-end rule pathway, contains at least two substrate-binding sites.
Kwon, Yong Tae, Lévy, Frédéric, Varshavsky, Alexander   +2 more
core   +1 more source

Controlling the properties of the micellar and gel phase by varying the counterion in functionalised-dipeptide systems [PDF]

, 2020
The micellar aggregates formed at high pH for dipeptide-based gelators can be varied by using different alkali metal salts to prepare the solutions.
Adams, Dave J., Cowieson, Nathan, Cui, Honggang, Fuentes-Caparrós, Ana M., Khunti, Nikul, Maklad, Osama, McAulay, Kate, Poole, Robert J., Seddon, Annela, Thomson, Lisa, Ucha, Pedro Agís, Wallace, Matthew, Wang, Han   +12 more
core   +6 more sources

First-principles molecular structure search with a genetic algorithm

, 2015
The identification of low-energy conformers for a given molecule is a fundamental problem in computational chemistry and cheminformatics. We assess here a conformer search that employs a genetic algorithm for sampling the low-energy segment of the ...
Baldauf, Carsten, Blum, Volker, Supady, Adriana   +2 more
core   +2 more sources