Results 31 to 40 of about 19,297 (179)

Cyclic Dipeptides Formation From Linear Dipeptides Under Potentially Prebiotic Earth Conditions

Frontiers in Chemistry, 2021
Cyclic dipeptides (DKPs) are peptide precursors and chiral catalysts in the prebiotic process. This study reports proline-containing DKPs that were spontaneously obtained from linear dipeptides under an aqueous solution. Significantly, the yields of DKPs
Yeting Guo, Yeting Guo, Jianxi Ying, Jianxi Ying, Dongru Sun, Dongru Sun, Yumeng Zhang, Minyang Zheng, Minyang Zheng, Ruiwen Ding, Ruiwen Ding, Yan Liu, Yufen Zhao, Yufen Zhao, Yufen Zhao, Yufen Zhao   +15 more
doaj   +1 more source

Synthesis and Antifungal Activity of Fmoc-Protected 1,2,4-Triazolyl-α-Amino Acids and Their Dipeptides Against Aspergillus Species

Biomolecules
In recent years, fungal infections have emerged as a significant health concern across veterinary species, especially in livestock such as cattle, where fungal diseases can result in considerable economic losses, as well as in humans.
Tatevik Sargsyan, Lala Stepanyan, Henrik Panosyan, Heghine Hakobyan, Monika Israyelyan, Avetis Tsaturyan, Nelli Hovhannisyan, Caterina Vicidomini, Anna Mkrtchyan, Ashot Saghyan, Giovanni N. Roviello   +10 more
doaj   +1 more source

Comprehensive Circulatory Metabolomics in ME/CFS Reveals Disrupted Metabolism of Acyl Lipids and Steroids

Metabolites, 2020
The latest worldwide prevalence rate projects that over 65 million patients suffer from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), an illness with known effects on the functioning of the immune and nervous systems.
Arnaud Germain, Dinesh K. Barupal, Susan M. Levine, Maureen R. Hanson   +3 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Amino Acid-Derived Metabolites from the Ascidian Aplidium sp.

Marine Drugs, 2015
Four new iodobenzene-containing dipeptides (1–4), a related bromotryptophan-containing dipeptide (5), and an iodophenethylamine (6) were isolated from the ascidian Aplidium sp. collected off the coast of Chuja-do, Korea.
Tae Hyung Won, Chang-Kwon Kim, So-Hyoung Lee, Boon Jo Rho, Sang Kook Lee, Dong-Chan Oh, Ki-Bong Oh, Jongheon Shin   +7 more
doaj   +1 more source

Beyond Primary Nucleation: Molecular Basis of Peptide Crystal Secondary Nucleation at Soft Interface

Advanced Functional Materials, EarlyView.
High spatiotemporal‐resolution atomic force microscopy directly resolved peptide secondary nucleation (SN) and growth characteristics and mechanisms on HOPG. The landscape of peptide nucleation sites, growth dynamics, molecular‐scale structures, phase transitions, and cross‐seeding processes were realized.
Linhao Sun, Abilesh Kumar, Ayhan Yurtsever   +2 more
wiley   +1 more source

Synthesis of S- and N,S-Heterocycle–Dipeptide Conjugates for Supramolecular Hydrogel Formation

Molecules
Small peptides with aromatic nuclei at the N-terminus have been shown to form bioactive, biocompatible, and biodegradable supramolecular peptide hydrogels.
Ana-Morgana G. P. Silva, Maria F. Martins, Carlos B. P. Oliveira, José A. Martins, Paula M. T. Ferreira, Maria-João R. P. Queiroz   +5 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Protein hydrolysates enhance recovery from drought stress in tomato plants: phenomic and metabolomic insights

Frontiers in Plant Science
IntroductionHigh-throughput phenotyping technologies together with metabolomics analysis can speed up the development of highly efficient and effective biostimulants for enhancing crop tolerance to drought stress. The aim of this study was to examine the
Marzia Leporino, Youssef Rouphael, Paolo Bonini, Paolo Bonini, Giuseppe Colla, Giuseppe Colla, Mariateresa Cardarelli   +6 more
doaj   +1 more source

Two Trypanocidal Dipeptides from the Roots of Zapoteca portoricensis (Fabaceae)

Molecules, 2014
Zapoteca portoricensis (Jacq) HM Hernández is used with remarkable efficacy in ethnomedicinal management of tonsillitis in the Eastern part of Nigeria. Previous pharmacological studies have validated the antiinflammatory and antimicrobial activities of ...
Ngozi Justina Nwodo, Festus Basden C. Okoye, Daowan Lai, Abdessamad Debbab, Reto Brun, Peter Proksch   +5 more
doaj   +1 more source