What do we know about atypical femoral fractures? Insights and enigmas [PDF]
Although the existence of atypical femoral fractures is well established and bisphosphonate therapy is thought to be a major risk factor, the underlying mechanisms are poorly understood.
B. Cortet, M. Audran, T. Thomas
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Patients with prostate cancer (PCa) on androgen-deprivation therapy (ADT) are at high risk of osteoporosis and fragility fractures. We aimed to provide some practical insights into the delivery of optimal bone health care for PCa patients, particularly
Enrique Casado+5 more
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A rat model of thyroid hormone-induced bone loss: Effect of antiresorptive agents on regional bone density and osteocalcin gene expression [PDF]
Thyroid hormone has been shown to stimulate bone resorption. Both endogenous hyperthyroidism and exogenous thyroxine suppressive therapy have been associated with reduction in bone mineral density (BMD), but the patholophysiology of thyroxine-induced ...
Kung, AWC, Ng, F
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In vitro and in vivo evaluation of superparamagnetic iron oxide nanoparticles coated by bisphosphonates: the effects of electrical charge and molecule length. [PDF]
Physicochemical coating properties are often considered to be determining factors for in vivo characteristics of superparamagnetic iron oxide nanoparticles, used as contrast agent in Magnetic Resonance Imaging (MRI). To investigate the electrical charge (
A. Karimi+6 more
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Designing a new molecular probe : the potential role for Tilmanocept (Lymphoseek) in the assessment of patients with painful hip and knee joint prostheses [PDF]
There is a long history of nuclear medicine developments in orthopaedics beginning in the early 20th century. Technetium-99m (99mTc) has a short half-life of six hours, emits 140 keV gamma rays and is the most widely used isotope, imaged with the Anger ...
Adesanya, Olu. O.+1 more
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Renal secretion of diphosphonates in rats
Diphosphonates, characterized by a P--C--P bond, are relatively new experimental drugs used for the treatment of myositis ossificans, dental calculus, nephrolithiasis and Paget's disease. These compounds are not metabolized and the fraction which is not taken up by the skeleton is excreted unchanged in the urine.
Herbert Fleisch+2 more
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Surface chemistry of heterobimetallic Ge-M (M = Mo, W) complexes in zeolite Y. [PDF]
The intrazeolite chemistry of the two germylene complexes Cl2CTHF)GeM(CO)5 (M = Mo, W) was studied with x-ray absorption spectroscopy (Ge, Mo, W edge EXAFS) and in-situ FTIR/TPD-MS techniques.
Bein, Thomas+2 more
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Severe congestive heart failure in elderly patient with Paget’s disease
Paget’s disease of bone is characterized by focal areas of increased bone turnover, affecting one or several bones throughout the skeleton. Paget’s disease is often asymptomatic, but can be associated with bone pain and other skeletal and non-skeletal ...
Lorenzo Palleschi, Eleonora Nunziata
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Development of Bone Targeting Drugs. [PDF]
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J.+6 more
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Bone scintigraphy with 99mTc diphosphonates may exhibit extraosseous lesions in addition to metastatic lesions. Multiple factors can affect extraosseous 99mTc methylene diphosphonate (MDP) uptake.
Funda Üstün+3 more
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