Results 71 to 80 of about 243,688 (335)

Rare human skin infection with Corynebacterium ulcerans: transmission by a domestic cat [PDF]

, 2018
Corynebacterium ulcerans is mainly known for its ability to cause animal infections. Some strains of C. ulcerans produce diphtheria toxin, which can cause life-threatening cardiopathies and neuropathies in humans. Human cutaneous C. ulcerans infection is
Bloemberg, G., Borelli, S., Corti, M., Eich, G., Hoelzle, L., Kutzner, H., Lautenschlager, S.   +6 more
core  

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti–PD-1 in melanoma

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Regulatory T cells (Tregs) infiltrate tumors in various cancers and promote an immunosuppressive microenvironment that hinders antitumor immunity. Denileukin diftitox, a diphtheria-toxin–based fusion protein that depletes Tregs, was approved
Laurene S Cheung, Juan Fu, Pankaj Kumar, Amit Kumar, Michael E. Urbanowski, Elizabeth A. Ihms, S. Parveen, C. K. Bullen, G. Patrick, R. Harrison, J. Murphy, D. Pardoll, W. Bishai   +12 more
semanticscholar   +1 more source

A 15‐year population‐based study on incidence and vaccination coverage in pediatric inflammatory bowel disease in Italy

Pediatric Investigation, EarlyView.
Increasing incidence of pediatric inflammatory bowel disease (IBD) and suboptimal vaccination coverage in Apulia, Italy (2009–2023). A total of 1044 incident cases of paediatric IBD were identified in the period 2009–2023 in Apulia, Italy, giving an average annual standardized incidence rate of 12.7/100 000. A significant increase in incidence occurred
Francesca Fortunato, Angelo Campanozzi, Michele Di Toma, Alessandra Marinari, Domenico Martinelli   +4 more
wiley   +1 more source

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, EarlyView.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

NGS-based phylogeny of diphtheria-related pathogenicity factors in different Corynebacterium spp. implies species-specific virulence transmission

BMC Microbiology, 2019
Diphtheria toxin (DT) is produced by toxigenic strains of the human pathogen Corynebacterium diphtheriae as well as zoonotic C. ulcerans and C. pseudotuberculosis.
A. Dangel, A. Berger, R. Konrad, A. Sing
semanticscholar   +1 more source

The Cinderella tree, Quillaja saponaria – A soap story

PLANTS, PEOPLE, PLANET, EarlyView.
Our current understanding of plants has been shaped by the entwining of different cultures. The Chilean soapbark tree, traditionally valued as a source of natural soap, was shown by serendipitous research in France in the 1900s to produce compounds that can boost the immune response to vaccines.
Anne Osbourn
wiley   +1 more source

Seroprevalence of diphtheria IgG antibodies among 5–20 years old in diphtheria affected regions during 2018–19: Evidence in support of the revised National Vaccine Policy for diphtheria in India

Clinical Epidemiology and Global Health
Background: Diphtheria continues to be a public health problem in India as it is re-emerging in several regions of the country. In recent times, apart from preschool-aged children, diphtheria outbreaks are seen to affect older children and adults.
Bindu R. Madhavi, Anitha Deva, Mahendra M. Reddy, P.M. Beena, S.N. Vijay Kumar   +4 more
doaj   +1 more source

Triage in the Time of Diphtheria

Western Journal of Emergency Medicine, 2020
Introduction: A diphtheria outbreak occurred in 2017 in Jakarta, Indonesia, during which our hospital was appointed as a referral hospital where patients with upper respiratory tract symptoms were sent for confirmation of the diagnosis and medical ...
Hadiki Habib, Hesty Kurniawaty
doaj   +1 more source

Diphtheria toxin time-resolved absorption and resonance ft-ir and raman biospectroscopy and density functional theory (dft) investigation of vibronic-mode coupling structure in vibrational spectra analysis: a spectroscopic study on an anti-cancer drug

Clinical Case Studies and Reports, 2019
Diphtheria toxin is an exotoxin secreted by Corynebacterium diphtheriae, the pathogenic bacterium that causes diphtheria. Unusually, the toxin gene is encoded by a bacteriophage (a virus that infects bacteria).
A. Heidari, J. Esposito, Angela Caissutti   +2 more
semanticscholar   +1 more source

Prioritization of the Sustainable Development Goals: Developing and Testing a Novel Framework Under Varying Geographic Scales

Sustainable Development, EarlyView.
ABSTRACT This study develops and tests a novel prioritization framework for the Sustainable Development Goals (SDGs) under varying geographic scales (regional, sub‐regional, national), focusing on the Middle East and North Africa (MENA) region as a pilot case.
Lea Issa, Mutasem El Fadel
wiley   +1 more source