Results 91 to 100 of about 314,031 (226)

Derivatives of MOPS: promising scaffolds for SARS coronaviruses Macro domain‐targeted inhibition

The FEBS Journal, EarlyView.
The SARS‐CoV/CoV‐2 genome encodes non‐structural protein 3, which contains a ‘Macro domain’. This protein domain exhibits antagonistic activity against interferon signaling, which disrupts the host innate immune response and can thus mediate viral escape, highlighting its therapeutic potential.
Oney Ortega Granda, Karine Alvarez, Benjamin Morin, Bruno Canard, François Ferron, Nadia Rabah   +5 more
wiley   +1 more source

Determination of low tetanus or diphtheria antitoxin titers in sera by a toxin neutralization assay and a modified toxin-binding inhibition test

Brazilian Journal of Medical and Biological Research, 2007
A method for the screening of tetanus and diphtheria antibodies in serum using anatoxin (inactivated toxin) instead of toxin was developed as an alternative to the in vivo toxin neutralization assay based on the toxin-binding inhibition test (TOBI test).
M.H. Sonobe, A.G. Trezena, F.B. Guilhen, V.L. Takano, F. Fratelli, D. Sakauchi, J.F. Morais, S.M.A. Prado, H.G. Higashi   +8 more
doaj  

ACTIVE IMMUNITY PRODUCED BY SO CALLED BALANCED OR NEUTRAL MIXTURES OF DIPHTHERIA TOXIN AND ANTITOXIN

Journal of Experimental Medicine, 1909
The foregoing and earlier data taken together demonstrate that an active immunity lasting several years can be produced in guinea-pigs, by the injection of toxin-antitoxin mixtures which have no recognizable harmful effect either immediate or remote ...
Theobald. Smith
semanticscholar   +1 more source

Functional verification of the diphtheria toxin A gene in a recombinant system

Journal of Animal Science and Biotechnology, 2012
Diphtheria toxin A (DTA), a segment of the diphtheria toxin (tox), inhibits protein synthesis in cells. When released from a cell, DTA is nontoxic and cannot enter other cells independently without the help of diphtheria toxin B.
Zhang Jingfeng, Wei Hengxi, Guo Xinzheng, Hu Minghua, Gao Fenglei, Li Li, Zhang Shouquan   +6 more
doaj   +1 more source

Notes on the Production of Immunity to Diphtheria Toxin

Journal of Hygiene, 1921
(a) Primary Stimulus. In animals possessing no normal antitoxin a single injection of toxin either “attenuated” or under cover of antitoxin, whether injected previously or at the same time or present in the form of passive immunity maternally transmitted,
A. Glenny, H. J. Südmersen
semanticscholar   +1 more source

Acute Myeloid Leukemia: 2025 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 100, Issue 5, Page 860-891, May 2025.
ABSTRACT Disease Overview Acute myeloid leukemia (AML) is a bone marrow stem cell cancer that is often fatal despite available treatments. Diagnosis, risk assessment, monitoring, and therapeutic management of AML have changed dramatically in the last decade due to increased pathophysiologic understanding, improved assessment technology, and the ...
Shai Shimony, Maximilian Stahl, Richard M. Stone   +2 more
wiley   +1 more source

Toxin-allelopathy among phytoplankton species prevents competitive exclusion [PDF]

Journal of Biological Systems, 2006, 2006
Toxic or allelopathic compounds liberated by toxin-producing phytoplankton (TPP) acts as a strong mediator in plankton dynamics. On an analysis of a set of phytoplankton biomass-data that have been collected by our group in the North-West part of the Bay of Bengal, and by analysis of a three-component mathematical model under a constant as well as a ...
arxiv  

CD11c‐Expressing Microglia Are Transient, Driven by Interactions With Apoptotic Cells

Glia, Volume 73, Issue 5, Page 1077-1089, May 2025.
Main Points Recognition of apoptotic cells drives transient microglial CD11c expression. CD11c microglia are highly phagocytic and have elevated lysosomal content. CD11c state is partly dependent on Axl and they transition out as apoptotic cells are cleared.
Nathaniel Ghena, Sarah R. Anderson, Jacqueline M. Roberts, Emmalyn Irvin, Joon Schwakopf, Alejandra Bosco, Monica L. Vetter   +6 more
wiley   +1 more source

NECESSITY OF TRANSLOCATION DOMAIN FOR REALISATION OF CYTOSTATIC EFFECT OF NON-TOXIC DERIVATIVES OF DIPHTHERIA TOXIN [PDF]

Biotechnologia Acta, 2018
The aim of the work was to evaluate in vitro the cytostatic effect of recombinant fragments of the non-toxic point mutant of diphtheria toxin — CRM197, which was suggested as a potent medication for treatment of triple negative breast cancer.
K. Y. Manoilov, O. I. Krynina, A. Ju. Labyntsev, S. I. Romaniuk, D. V. Kolybo   +4 more
doaj   +1 more source

Bruceine A Inhibits Cell Proliferation by Targeting the USP13/PARP1 Signalling Pathway in Multiple Myeloma

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 5, May 2025.
USP13 is a promising therapeutic target for cellular proliferation in multiple myeloma. Bruceine A can retard the development of multiple myeloma by targeting USP13/PARP1‐mediated DNA damage repair and triggering cell apoptosis. ABSTRACT Multiple myeloma (MM) is an incurable hematologic malignancy, driving significant interest in the discovery of novel
Mengjie Guo, Han Meng, Yi Sun, Lianxin Zhou, Tingting Hu, Tianyi Yu, Haowen Bai, Yuanjiao Zhang, Chunyan Gu, Ye Yang   +9 more
wiley   +1 more source