Efficacy of antiplatelet therapy in secondary prevention following lacunar stroke:Pooled analysis of randomized trials [PDF]
, 2015 Background and Purpose: Lacunar stroke accounts for ≈25% of ischemic stroke, but optimal antiplatelet regimen to prevent stroke recurrence remains unclear.
Benavente, Oscar R. +5 more
core +1 more source
Single‐cell digital twins identify drug targets and repurposable medicine in Alzheimer’s disease [PDF]
Alzheimers DementAbstract Background Alzheimer’s disease (AD) is a complex and poorly understood neurodegenerative disorder with a lack of effective treatments. Novel approaches for identifying FDA‐approved drugs with potential for AD treatment hold promise to address this challenge.
Ren Y, Pieper A, Cummings J, Cheng F.
europepmc +2 more sources
Towards understanding the clinical significance of QT peak prolongation: a novel marker of myocardial ischemia independently demonstrated in two prospective studies [PDF]
, 2015 Background: QT peak prolongation identified patients at risk of death or non-fatal MI. We tested the hypothesis that QT peak prolongation might be associated with significant myocardial ischaemia in two separate cohorts to see how widely applicable the ...
Ball, Jeff B +10 more
core +1 more source
The Surgery Journal, 2018 Introduction In the Netherlands, clopidogrel monotherapy increasingly replaces acetylsalicylic acid and extended release dipyridamole as the first-choice antiplatelet therapy after ischemic stroke.
Martijn S. Marsman +6 more
doaj +1 more source
Efficacy, Safety, and Timing of Anticoagulant Thromboprophylaxis for the Prevention of Venous Thromboembolism in Patients With Acute Spinal Cord Injury: A Systematic Review [PDF]
, 2017 Study Design: Systematic review. Objectives: The objective of this study was to answer 5 key questions: What is the comparative effectiveness and safety of (1a) anticoagulant thromboprophylaxis compared to no prophylaxis, placebo, or another ...
Arnold, Paul M. +10 more
core +2 more sources
Effects of Dpyridamole on Histopathology of Salivary Glands in Rabbits [PDF]
Al-Rafidain Dental JournalAims: Dipyridamole is a well-known coronary vasodilator. It is an adenosine reuptake inhibitor leading to increased blood levels of adenosine. So, this study aims to investigate the effects of systemic administration of dipyridamole on the salivary gland
Abdulsattar S. Mahmood +2 more
doaj +1 more source
Adherence to secondary stroke prevention strategies - Results from the German stroke data bank [PDF]
, 2003 Only very limited data are available concerning patient adherence to antithrombotic medication intended to prevent a recurrent stroke. Reduced adherence and compliance could significantly influence the effects of any stroke prevention strategies.
Busse, O. +4 more
core +1 more source
Metabolic and functional consequences of cytosolic 5′-nucleotidase-IA overexpression in neonatal rat cardiomyocytes [PDF]
, 2003 Adenosine exerts a spectrum of energy-preserving actions on the heart negative chronotropic effects. The pathways leading to adenosine formation have remained controversial.
Curto, Maria de Los Angeles +3 more
core +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aims To explore sex‐specific heterogeneity in the prognostic discrimination of inflammatory markers for mortality across different glycaemic states. Methods This prospective cohort study included 450 438 participants from the UK Biobank (median follow‐up: 15.3 years), stratified by sex and glycaemic status.
Yawen Zhang +5 more
wiley +1 more source
Management tactics in patients with chronic cerebral ischemia during COVID-19 pandemic
Неврология, нейропсихиатрия, психосоматика, 2021 The article describes the current state of evidence of hypertension and diabetes mellitus roles in the pathophysiology of chronic cerebral ischemia (CCI).
A. A. Kulesh
doaj +1 more source