Results 121 to 130 of about 48,247 (244)

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, EarlyView.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Serum Bile Acids Are Useful Indicators of Intrahepatic Recurrence After Initial Curative Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim Bile acids accumulation in hepatocytes causes liver damage and contributes to the development of hepatocellular carcinoma. However, the association between serum bile acid levels and postoperative intrahepatic recurrence in hepatocellular carcinoma remains unclear.
Tomoaki Bekki, Masahiro Ohira, Yuki Imaoka, Seiichi Simizu, Tomoyuki Abe, Shintaro Kuroda, Hiroyuki Tahara, Kentaro Ide, Tsuyoshi Kobayashi, Hideki Ohdan   +9 more
wiley   +1 more source

Less Restrictive Medicaid Policies for Direct-Acting Antiviral Access Are Associated With Greater Declines in Hepatocellular Carcinoma Deaths. [PDF]

Cancer Med
Lupu GV, Behera B, Barritt AS, Deutsch-Link S, Giang J, Green EW, Fix OK, Shah ND, Shroff H, Moon AM.   +9 more
europepmc   +1 more source

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source

A Case Report of Direct-Acting Antiviral Therapy for Chronic Hepatitis C in a Patient With Dementia Treated in Collaboration With Multiple Specialists. [PDF]

Case Reports Hepatol
Tanie T, Kanda K, Fujikawa H.
europepmc   +1 more source

Direct-acting antiviral therapy in HCV patients: a retrospective study of the pre- and post-treatment impact in Saudi Arabia. [PDF]

BMC Infect Dis
Alayidh FS, Woodman A, Zakary NY, Al-Ansari RY, Chaudhry S, Alsaadi AO, Alharbi KA, Alamri BA, Alhomud SM, Albather SH, Bataweel SA, Madkhali NA, Alzahrani SJ, Ehtesham Z.   +13 more
europepmc   +1 more source

Repurposing Hepatitis C Direct-Acting Antivirals Against COVID-19

Journal of Clinical and Experimental Hepatology, 2021
Kumar, Pramod, Kulkarni, Anand, Sharma, Mithun, Rao, Padaki N.   +3 more
openaire   +3 more sources

Evaluating long-term outcomes of direct-acting antiviral therapy in chronic hepatitis C: A retrospective study. [PDF]

Medicine (Baltimore)
Sung BR, Shim SG, Kim KM, Lee JW, Kim JY, Lee BK, Jun CH, Kwan BS.   +7 more
europepmc   +1 more source

Beyond direct-acting antiviral therapy: Characterizing mental health conditions and depressive symptoms among patients recently treated for hepatitis C. [PDF]

PLoS One
Kelly SE, Ajidahun A, Bytelaar S, Ding E, Fulton C, Harris M, Sykes G, Ly J, Barrios R, Hull MW, Montaner JSG, Salters K.   +11 more
europepmc   +1 more source

More Than a Buffer in Biochemistry: Tris as an Architect and Gatekeeper of Metal–Oxo Assembly

Angewandte Chemie International Edition, EarlyView.
Tris(hydroxymethyl)aminomethane, depicted as an octopus, acts as an alkoxy ligand, chelator, and structure‐directing buffer that programs polyoxometalate's speciation, nucleation, and heterometal insertion in aqueous solution. ABSTRACT Polyoxometalates (POMs, molecular metal–oxo clusters) are typically studied and applied in aqueous media, where ...
Nadiia I. Gumerova, Annette Rompel
wiley   +1 more source