Results 141 to 150 of about 3,844,628 (256)

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Models of care for hepatitis C in the era of direct acting antiviral therapy

, 2018
In 2014, only 1% of Australians with hepatitis C had received treatment. Low treatment rates mean that hepatitis C is a leading cause of liver cancer and liver failure.
AMANDA JANE WADE (5181554)
core   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

Expanding Genetic Code to Generate Human Brain Organoids with Both Vasculature and Microglia‐Like Cells

Advanced Science, EarlyView.
Using genetic code expansion, we engineered vascularized human cerebral organoids (vhCOs) with microglia‐like cells and blood‐brain barrier features. vhCOs recapitulate neurovascular interactions, regional identities, and neuronal subtypes resembling the fetal brain.
Haishuang Lin, Yaqing Wang, Hu Du, Yuxin Qin, Haoyu Zhang, Peng Wang, Lin Wei, Jianhua Qin   +7 more
wiley   +1 more source

Boceprevir: New possibilities for the antiviral treatment of chronic hepatitis C

Терапевтический архив, 2013
The given clinical review covers current antiviral therapy for chronic hepatitis C. Traditional antiviral therapy with pegylated interferon-α and ribavirin in patients with chronic hepatitis C virus genotype 1 allows a sustained virological response (SVR)
I G Nikitin, I E Baĭkova, L M Gogova, V M Volynkina, V A Kisliakov   +4 more
doaj  

Persistence of fibrogenic process in direct-acting antiviral (DAA) treated patients? [PDF]

ExRNA, 2022
Cecilia Battistelli, Marco Tripodi
doaj   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Forest plot showing the achievement of SVR in CHC patients with low baseline HCV RNA treated with pegylated interferon α-2 plus ribavirin or pegylated interferon α-2 plus ribavirin plus a direct-acting antiviral.

, 2014
Forest plot showing the achievement of SVR in CHC patients with low baseline HCV RNA treated with pegylated interferon α-2 plus ribavirin or pegylated interferon α-2 plus ribavirin plus a direct-acting antiviral.
Caterina Sagnelli (430094), Evangelista Sagnelli (430095), Nicola Coppola (430089), Italo F. Angelillo (300520), Mariantonietta Pisaturo (430090)   +4 more
core   +1 more source

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Supplemental_File_No_1 – Supplemental material for ‘Real-life’ experience with direct-acting antiviral agents for hepatitis C virus in end-stage renal disease

, 2018
Supplemental material, Supplemental_File_No_1 for ‘Real-life’ experience with direct-acting antiviral agents for hepatitis C virus in end-stage renal disease by Rebeca García-Agudo, Sami Aoufi-Rabih, Mercedes Salgueira-Lazo, Carmen González-Corvillo and ...
Carmen González-Corvillo (5991467), Sami Aoufi-Rabih (5991461), Mercedes Salgueira-Lazo (5991464), Rebeca García-Agudo (5991458), Fabrizio Fabrizi (5042318)   +4 more
core   +1 more source