Results 171 to 180 of about 3,746,725 (298)

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Cardiac safety of sofosbuvir-based direct-acting antivirals in hepatitis C patients with pre-existing heart disease. [PDF]

Clinics (Sao Paulo)
Hanafy AS, Mohamed MS, Attia O, Mohammed AFE, Hassaneen AM, Naguib R, Fahmy EK, Elkattawy HA.   +7 more
europepmc   +1 more source

VCP‐Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Qian Zhao, Lisa Andriani, Yin‐Ling Zhang, Shao‐Ying Yang, Yun‐Xiao Ling, Min‐Ying Huang, Jia‐Yang Cai, Fang‐Lin Zhang, Xin Hu, A‐Yong Cao, Zhi‐Min Shao, Guang‐Yu Liu, Da‐Qiang Li   +12 more
wiley   +1 more source

Influenza in today: direct-acting antiviral therapy

Медицинский совет, 2015
Influenza is an acute infectious disease caused by influenza virus (Orthomyxoviridae family) which affects up to 15% of the world population in the cold season. The relevance of the disease is reflected in the statistics: every year, up to 500 million people get sick with influenza globally, of which 2 million cases are fatal.
openaire   +1 more source

Are Direct-Acting Antivirals Effective and Safe for Hepatitis C Patients with Arterial Hypertension? Evidence from a Large Retrospective Real-World Study. [PDF]

Viruses
Brzdęk M, Rzymski P, Zarębska-Michaluk D, Poniedziałek B, Lorenc B, Berak H, Mazur W, Janocha-Litwin J, Tudrujek-Zdunek M, Sitko M, Klapaczyński J, Flisiak R.   +11 more
europepmc   +1 more source

A Fish MDA5 Integrates Canonical RIG‐I and MDA5 Ligand Recognition

Advanced Science, EarlyView.
These results show that the large yellow croaker lacks RIG‐I, yet its MDA5 senses both 5′ppp‐dsRNA and long dsRNA. A flexible RNA‐capping loop in the MDA5 C‐terminal domain enables two ligand‐binding modes. This dual recognition signals through MAVS–STING–TBK1/IRF3 and induces type I interferons, revealing unexpected plasticity in vertebrate antiviral ...
Wenxing Li, Yuan Feng, Huazhi Chen, Jiamei Liu, Álvaro Fernández Montero, Jiangtao Gao, Jingqun Ao, Xinhua Chen   +7 more
wiley   +1 more source

Treatment with Direct-Acting Antivirals in Patients with HCV Infection After Liver Transplantation. [PDF]

J Clin Med
Brzdęk M, Zarębska-Michaluk D, Tronina O, Laurans Ł, Janczewska E, Dybowska D, Parfieniuk-Kowerda A, Tudrujek-Zdunek M, Białkowska-Warzecha J, Janocha-Litwin J, Flisiak R.   +10 more
europepmc   +1 more source

An Oral Antiviral Combination Against Severe COVID‐19 Enabled by the Synergistic Mechanisms of Action of Auranofin and Remdesivir

Advanced Science, EarlyView.
FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun, Rohan Narayan, Santhosh Kambaiah Nagaraj, Rishad Shiraz, Abinaya Kaliappan, Sumandeep Kaur, Ankur Singh, Siva Shanmugam Selvaraj, Gudepalya Renukaiah Rudramurthy, Chakenahalli Naveenkumar, Shridhar Narayanan, Radha Krishan Shandil, Shailly Tomar, Shashank Tripathi   +13 more
wiley   +1 more source

Recent progress in anti-Chikungunya virus drug discovery: Focus on the viral life cycle and direct-acting antivirals. [PDF]

Virol Sin
Liu C, Pan S, Gao M, Zhang Y, Zhang L, Lin B, Jiang X.   +6 more
europepmc   +1 more source

Large Oncosomes Induce Pro‐Metastatic Stromal‐Myeloid Reprogramming

Advanced Science, EarlyView.
Large oncosomes systemically reprogram bone marrow mesenchymal stem cells through innate nucleic acid sensing, driving inflammatory and immunosuppressive remodeling that supports a metastasis‐permissive bone marrow environment, revealing a novel tumor‐host communication axis in cancer. ABSTRACT Bone metastasis can be facilitated by systemic remodeling,
Taylon Felipe Silva, Virginia Marcia Concato‐Lopes, Fatima Bedier, Lauren Newman, Diana Kitka, Jamelle Brown, Blandine Victor, Minhyung Kim, Tatyana Vagner, Catherine Grasso, Dmitriy Sheyn, Sungyong You, Michael R. Freeman, Fayyaz S. Sutterwala, Helen S. Goodridge, Caroline Jefferies, Paola de Candia, Jlenia Guarnerio, Dolores Di Vizio   +18 more
wiley   +1 more source