Therapeutic Advances Against ZIKV: A Quick Response, a Long Way to Go
Pharmaceuticals, 2019 Zika virus (ZIKV) is a mosquito-borne flavivirus that spread throughout the American continent in 2015 causing considerable worldwide social and health alarm due to its association with ocular lesions and microcephaly in newborns, and Guillain−Barr&
Juan-Carlos Saiz
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The occurrence of thrombotic thrombocytopenic purpura during treatment of HCV with direct-acting antiviral agents [PDF]
African Journal of Gastroenterology and Hepatology, 2018 Background and aim Experts have reported thrombocytopenia is linked to chronic liver disease in up to 70% of patients with advanced fibrosis and portal hypertension. The occurrence of thrombotic thrombocytopenic purpura (TTP) with HCV infection is a rare
Amr Hanafy, Waseem Seleem, Salem Mohamed
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The Complex Interplay Relationship between HCV Infection, Direct-Acting Antiviral Therapy, and Hepatocellular Carcinoma Occurrence [PDF]
, 2023 : The new direct-acting antivirals (DAAs) for chronic hepatitis C (CHC) are highly effective, despite the short duration of treatment, and very tolerable [...]
Erica Villa +5 more
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SHARED: An International Collaboration to Unravel Hepatitis C Resistance
Viruses, 2021 The advent of direct-acting antivirals (DAAs) has transformed the treatment landscape of hepatitis C [...]
Anita Y.M. Howe +12 more
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New horizons in hepatitis C antiviral therapy with direct-acting antivirals [PDF]
Hepatology, 2013 Abstract Most direct-acting antivirals (DAAs) that are being developed as therapy against hepatitis C virus target the NS3/4A protease, the NS5A protein, and the NS5B polymerase. The latter enzyme offers different target sites: the catalytic domain for nucleos(t)ide analogues as well as a number of allosteric sites ...
Alessio, Aghemo, Raffaele, De Francesco
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Direct-acting antivirals lower mortality and recurrence in HCV-related hepatocellular carcinoma post liver resection : A multicenter international study [PDF]
Background: The impact of treatment on hepatitis C virus with direct-acting antivirals on 90-day postoperative outcomes, overall survival, and recurrence-free survival in patients after liver resection for hepatocellular carcinoma is unknown. Methods: We
O'Kane, Grainne M. +25 more
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Pharmaceuticals, 2023 Combining antiviral drugs with different mechanisms of action can help prevent the development of resistance by attacking the infectious agent through multiple pathways.
Liliana Betancur-Galvis +4 more
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Role of Liver Stiffness Measurement in Predicting HCC Occurrence in Direct-Acting Antivirals Setting: A Real-Life Experience [PDF]
, 2019 The aim of this study was to evaluate the relationship between the liver stiffness measurement and the risk of developing hepatocellular carcinoma (HCC) in HCV cirrhotic patients undergoing new direct-acting ...
Imparato M. +31 more
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Frontiers in Microbiology, 2023 This article systematically presents the current clinically significant therapeutic developments for the treatment of COVID-19 by providing an in-depth review of molecular mechanisms of action for SARS-CoV-2 antivirals and critically analyzing the ...
Oana Săndulescu +8 more
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HIV/HCV Antiviral Drug Interactions in the Era of Direct-acting Antivirals [PDF]
Journal of Clinical and Translational Hepatology, 2016 Therapy for human immunodeficiency virus (HIV) and chronic hepatitis C has evolved over the past decade, resulting in better control of infection and clinical outcomes; however, drug-drug interactions remain a significant hazard. Joint recommendations from the American Association for the Study of Liver Diseases and the Infectious Diseases Society of ...
Rice, Donald P. +3 more
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