Results 91 to 100 of about 19,887 (300)

Mesenchymal Stromal Cell‐Mediated Intercellular Communication: Mapping the Interactome for Skeletal Muscle Homeostasis and Regeneration

Advanced Science, EarlyView.
Liu et al. define a systems‐level interactome of fibroadipogenic progenitor (FAP)‐mediated signaling in skeletal muscle by integrating single‐cell transcriptomics with FAP depletion‐based perturbation analysis. Functional interrogation using a conditioned media bioassay links predicted signaling to multicellular outcomes, establishing a framework to ...
Xingyu Liu, Edgar E. Perez Carbajal, Yih‐Chii Hwang, Sahil A. Mapkar, Benjamin W. Gilman, Sarah A. Bliss, Lam B. Tran, Kalgi T. Mehta, Jacob O. Banyasz, Ming Yu, Reynold R. Liu, Matthew N. Ly, Christapher S. Morrissey, Michael N. Wosczyna   +13 more
wiley   +1 more source

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

Lipid Profile and Cardiovascular Risk Modification after Hepatitis C Virus Eradication

Pathogens
The eradication of the hepatitis C virus (HCV) has revolutionized the hepatology paradigm, halting the progression of advanced liver disease in patients with chronic infection and reducing the risk of hepatocarcinoma.
Andrea Pascual-Oliver, Diego Casas-Deza, Carmen Yagüe-Caballero, Jose M. Arbones-Mainar, Vanesa Bernal-Monterde   +4 more
doaj   +1 more source

Chronic hepatitis c treatment failure with directly acting antivirals, causes, solutions: case presentation and literature review.

, 2023
Hepatitis C virus infection is a global public health concern. If left untreated, chronic hepatitis C can progress gradually to cirrhosis, chronic liver failure and hepatocellular carcinoma.
Lisaitė, Urtė,
core  

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

Advanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang, Dandan Zong, Rui Liu, Yubo Wang, Qingqing Gu, Yao Yao, Wenfang Zheng, Mengmeng Yuan, Simeng Wang, Rongrong Cui, Daxu Li, Siwen Dang, Peng Hou   +12 more
wiley   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Direct-acting antivirals for the treatment of kidney transplant patients with chronic hepatitis C virus infection in Spain: a long-term prospective observational study [PDF]

, 2019
Kidney Transplantation; Hepatitis C; Direct-acting antivirals therapyTrasplante de riñón; Hepatitis C; Terapia antiviral de acción directaTrasplantament de ronyó; Hepatitis C; Teràpia antiviral d’acció directaBackground.
Perelló, M., Franco, Antonio, Alonso, A., Paul, J., Zarraga, Sofia, Sanchez Fructuoso, Ana Isabel, Guirado, L., Gonzalez-Corvillo, Carmen, Perello, Manel, Mazuecos, Auxiliadora, Lauzurica, Ricardo, Rodriguez-Benot, Alberto, De Gracia Guindo, M.D.C., Crespo Barrio, Marta, Sanchez-Fructuoso, Ana, Zárraga, S., Ruiz, Juan Carlos, Hernández, D., Rodríguez-Benot, A., Alonso Hernández, Ángel, Guirado, Luis, Gentil, M.A., Hernandez, Domingo, Jiménez Martín, Carlos, Perelló Carrascosa, Manel, Alonso, Angel, Sánchez-Fructuoso, A., Jiménez, C., Jimenez, Carlos, Franco, A., Llorente, S., de Gracia Guindo, Maria Del Carmen, Ruiz, J.C., Llorente, Santiago, Beneyto, Isabel, Beneyto, I., Lauzurica, R., Gentil, Miguel Ángel, Crespo, Marta, Diaz-Corte, Carmen, Crespo, M., Paul, Javier, González-Corvillo, C., Universitat Autònoma de Barcelona, Mazuecos, A., Díaz-Corte, C.   +45 more
core   +1 more source

UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

Advanced Science, EarlyView.
ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function.
Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal   +7 more
wiley   +1 more source

Profile of alisporivir and its potential in the treatment of hepatitis C

Drug Design, Development and Therapy, 2013
Philippe A Gallay,1 Kai Lin21Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, 2Permeon Biologics Inc, One Kendall Square, Cambridge, MA, USAAbstract: Two classes of hepatitis C antiviral agents currently exist,
Gallay PA, Lin K
doaj  

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source