Results 121 to 130 of about 16,333 (257)

Overcoming Transmission Barriers: A Dual‐Functional Adhesive Hydrogel for Direct Monkeypox Virus Neutralization and Wound Healing

Advanced Science, EarlyView.
MPXV infection leads to persistent viral replication and severe local inflammation, while existing treatments cannot simultaneously remove viruses and repair injured tissue. This study constructs Polymer@mPDA@Gel hydrogel via a two‐step hierarchical assembly method: mPDA anchors photothermal polymers to form antiviral photothermal subunits, which are ...
Ming Zhang, Jiaxin Tian, Xiaolong Zhu, Xiao Li, Xiangshu Qiu, Yuanyuan Li, Ben Zhong Tang, Ning Shi   +7 more
wiley   +1 more source

Correction: The Impact of Organic Anion-Transporting Polypeptide (OATP) Variants on the Side Effects of Direct-Acting Antivirals in Hepatitis C Patients. [PDF]

Cureus
Altintas Z, Altintas E.
europepmc   +1 more source

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Efficacy and Safety of Direct-Acting Antivirals in Patients with Hepatitis C Infection: Nationwide Real-life Data from Türkiye. [PDF]

Turk J Gastroenterol
Gunduz A, Öztoprak NÇ, Sarı ND, Kurtaran B, Önlen Y, Senates E, Zerdali E, Karsen H, Batırel A, Ali RK, Güner R, Yamazhan T, Kose S, Erben N, Ince N, Köksal İ, Sarıgül Yıldırım F, Yoruk G, Komur S, Bal T, Kaya S, Esen Ş, Günal Ö, Yıldız IE, Inan D, Barut Ş, Namıduru M, Tosun S, Türker K, Sener A, Hızel K, Baykam N, Duygu F, Akıncı E, Can G, User U, Gül HC, Akbulut A, Çelebi G, Sünnetçioğlu M, Karabay O, Kumbasar Karaosmanoğlu H, Sırmatel F, Tabak F, Hep-C Turkey Study Group.   +44 more
europepmc   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Advanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye, Yihang Huang, Bohao Han, Lei Zhang, Can Yu, Yang Yang, Bing Liu, Yongping Jian, Zhixiang Xu, Cheng Zeng   +9 more
wiley   +1 more source

Treatment with Direct-Acting Antivirals in Patients with HCV Infection After Liver Transplantation. [PDF]

J Clin Med
Brzdęk M, Zarębska-Michaluk D, Tronina O, Laurans Ł, Janczewska E, Dybowska D, Parfieniuk-Kowerda A, Tudrujek-Zdunek M, Białkowska-Warzecha J, Janocha-Litwin J, Flisiak R.   +10 more
europepmc   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Risk of type 2 diabetes mellitus after treatment with direct-acting antivirals for hepatitis C virus in people with HIV. [PDF]

AIDS
Chalouni M, Torgersen J, Rentsch CT, Van Santen DK, Jarrin I, Klein MB, Young J, Gill MJ, Epstein RL, Linas B, Zangerle R, Surial B, Nemeth J, Touloumi G, Papadopoulos A, Wittkop L, Van Der Valk M, Boyd A, Monforte AD, Puoti M, Logan RW, Rein SM, Miro JM, Berenguer J, Hernán MA, Lodi S.   +25 more
europepmc   +1 more source

Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders

Advanced Science, EarlyView.
Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley   +1 more source

Chronic Hepatitis C in the Direct-Acting Antivirals Era: Carcinogenesis and Clinical Implications. [PDF]

Diseases
Aydin Y, Kurt R, Tahan V, Daglilar E.
europepmc   +1 more source