Results 231 to 240 of about 34,959 (356)

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects [PDF]

, 2017
Diamond, Michael S, et al,, Govero, Jennifer   +2 more
core   +2 more sources

Hepatitis C missed diagnostic opportunities: The role of reflex viral load testing in the era of direct acting antivirals, a descriptive South African study from 2017 to 2021. [PDF]

S Afr J Infect Dis
Mthiyane H, Mashishi B, Patjane MA, Honwana N, Prabdial-Sing N, Hans L, Mbenenge N, Reddy B, Bangalee A, Treurnicht FK.   +9 more
europepmc   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Short-Term Clinical and Immunologic Outcomes Conditional on SVR12 in Hepatitis C Virus-Associated Cryoglobulinemic Vasculitis Treated With Direct-Acting Antivirals: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Boonpheng B, Ungprasert P.
europepmc   +1 more source

Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology

Biotechnology and Bioengineering, EarlyView.
ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman, Emily Lathrop, Aurelia Attal‐Juncqua, Matthew Nicotra, Allison Berke   +4 more
wiley   +1 more source

Cause-specific mortality following sustained virologic response in hepatitis C patients treated with direct-acting antivirals: a standardized mortality ratio analysis. [PDF]

Sci Rep
Mawatari S, Tanoue S, Kumagai K, Oda K, Toyodome A, Sakae H, Fujisaki K, Inada Y, Uto H, Saisyoji A, Hiramine Y, Tabu K, Ijuin S, Hori T, Tamai T, Moriuchi A, Kanmura S, Ido A.   +17 more
europepmc   +1 more source

A Mechanistic Model of rAAV Production in Synthetic Cell Lines

Biotechnology and Bioengineering, EarlyView.
ABSTRACT The recombinant adeno‐associated virus (rAAV) is a widely used vector for gene therapy. Its manufacturing faces significant challenges in producing the large quantities of vectors needed for clinical applications and reducing empty particles.
Prahalad Srinivasan, Han‐Jung Kuo, Yu‐Chieh Lin, Yen‐An Lu, Wei‐Shou Hu, Qi Zhang   +5 more
wiley   +1 more source

HCV avidity as a tool for detection of recent HCV infection: sensitivity depends on HCV genotype [PDF]

, 2018
Araujo, Barreiro, Coppola, Coppola, Coughlin, Cunningham, Dominguez, Dore, Feld, Gaudy-Graffin, Genders, Giese, Gower, Grebely, Grebely, Grebely, Grebely, Greiner, Gutiérrez, Hajarizadeh, Hajarizadeh, Hajarizadeh, Hauser, Kanno, Kassanjee, Kassanjee, Kassanjee, Klimashevskaya, Mangia, Martin, Netski, Parekh, Patel, Pawlotsky, Pawlotsky, Polanec, Sacks-Davis, Sagnelli, Shepherd, Sulkowski, Thacker, Thomson, Tomkins, Vickerman, Ward, Wiessing   +45 more
core   +1 more source

Impact of Direct-Acting Antivirals on Extrahepatic Manifestations in Chronic Hepatitis C: A Narrative Review with a Hermeneutic Approach. [PDF]

Healthcare (Basel)
Balta AAS, Ignat MD, Barbu RE, Dumitru C, Radaschin DS, Bulza V, Mateescu Costin SA, Pleșea-Condratovici C, Baroiu L.   +8 more
europepmc   +1 more source

High efficacy of generic and brand direct acting antivirals in treatment of chronic hepatitis C

, 2018
Mai Abozeid, Ayman Alsebaey, Eman Abdelsameea, Warda Othman, Mostafa Elhelbawy, Amr Rgab, M.D. REEM A. EL-HADIDY NEVEEN M. EL-FAYOMY, Tamer Samir Abdel-Ghafar, Mervat Abdelkareem, Alyaa Sabry, Marwa Fekry, Nashwa Shebl, Eman Rewisha, Imam Waked   +13 more
openalex   +1 more source