Results 221 to 230 of about 17,033 (261)
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Direct acting antivirals failure: cause and retreatment options
Expert Review of Gastroenterology & Hepatology, 2018Chronic hepatitis C (HCV) infection is a systemic life-threatening condition that can lead to hepatic and extra-hepatic complications. Sustained virological response (SVR) is associated with a regression of most liver and non-liver manifestations, which reduce mortality.
Lucia, Parlati, Stanislas, Pol
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Direct-acting antiviral treatment for patients with hepatocellular carcinoma
Current Opinion in Gastroenterology, 2018Hepatocellular carcinoma (HCC) affects a significant portion of patients with hepatitis C. The use of direct-acting antiviral (DAA) agents has transformed the disease outcomes in this patient group.Hepatitis C virus (HCV) response to DAAs can be affected by the presence of HCC, whereas DAA therapy may affect the risk of HCC recurrence in patients with ...
Tatyana, Kushner +2 more
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Role of Liver Biopsy in the Era of Direct-Acting Antivirals
Current Gastroenterology Reports, 2013An accurate assessment of the degree of fibrosis or presence of cirrhosis is critical both for the appropriate management of, and to provide prognosis for, patients with chronic hepatitis C infection. In the new era of direct acting antivirals, large numbers of patients may enter therapy, and although liver biopsy remains the gold standard, it is not ...
Humberto C, Gonzalez +2 more
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Direct-acting antivirals: the endgame for hepatitis C?
Current Opinion in Virology, 2017Directly-acting antivirals (DAA) have finally allowed all patients to be potentially cured from chronic hepatitis C (HCV) infection. All-oral, Interferon (IFN)-free regimens are based upon the combination of molecules targeting different sites of the HCV replication process.
Roberta, D'Ambrosio +3 more
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IL28B in the Era of Direct-acting Antivirals for Hepatitis C
Journal of Clinical Gastroenterology, 2013The IL28B genotype is the strongest baseline predictor of hepatitis C treatment response with peginterferon-α and ribavirin. In 2011, 2 protease inhibitors were approved for genotype 1 infection in combination with peginterferon-α and ribavirin, and boceprevir and telaprevir attenuate the association between the IL28B genotype and treatment response ...
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[Direct-acting antiviral-resistant variant].
Nihon rinsho. Japanese journal of clinical medicine, 2015Recently, IFN-free NS5A inhibitor daclatasvir and protease inhibitor asunaprevir combination treatment was approved for genotype 1b HCV-infected patients who were ineligible or who failed to respond to previous therapies. NS5A inhibitor-resistant variants occasionally exist in HCV-infected patients who have never been exposed to direct-acting ...
Michio, Imamura, Kazuaki, Chayama
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Direct-acting antivirals for paediatric HCV: we got there
Nature Reviews Gastroenterology & Hepatology, 2017In a new report, adolescents with genotype 2 or 3 HCV infection who were given sofosbuvir and ribavirin showed a near 100% sustained virologic response. This study is the beginning of a new wave of treatments for paediatric HCV infection, forming part of a global strategy to eradicate viral hepatitis.
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Direct-acting antiviral treatment for HCV
The Lancet Infectious Diseases, 2016Stelliana, Goutzamanis +4 more
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Direct acting antiviral therapy after liver transplantation
Current Opinion in Gastroenterology, 2016Historically, postliver transplant patients with chronic hepatitis C have had worse outcomes than nonhepatitis C-related causes because of accelerated fibrosis posttransplantation and the lack of effective well tolerated therapies for hepatitis C, and posttransplant hepatitis C patients have been considered a special population.
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Direct-Acting Antiviral Agents
Clinics in Liver Disease, 2015Tatyana Kushner, Vandana Khungar
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