Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Tanjungpura Journal of Coaching ResearchBackground and Study Aim. The Teaching Games for Understanding (TGFU) model emphasizes tactical understanding of the game, while Direct Instruction is more oriented towards explicit instruction and repetitive practice.
Zaniar Dwi Prihatin Ciptadi +3 more
doaj +1 more source
Guidelines for Facilitating Direct Instruction of Generalized Social Behavior: Teaching the General Case. [PDF]
Behav Anal Pract, 2021 Scott TM, Dubuque EM.
europepmc +1 more source
Instruction sequences with indirect jumps [PDF]
, 2007 We study sequential programs that are instruction sequences with direct and indirect jump instructions. The intuition is that indirect jump instructions are jump instructions where the position of the instruction to jump to is the content of some memory ...
Bergstra, J. A., Middelburg, C. A.
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Integrating Scratch with Project-Based Learning to Cultivate Students' Academic Performance
Journal of Innovation in Educational and Cultural ResearchThis study addresses the challenge of enhancing students' academic performance, including creativity, learning achievement, problem-solving ability, motivation, and attitude, by integrating problem-solving into biology lessons through Scratch and Project-
Wenny Pinta Litna Tarigan +4 more
doaj +1 more source
Learning Basketball Using Direct Instruction and Tactical Game Approach Methodologies. [PDF]
Children (Basel), 2021 González-Espinosa S +3 more
europepmc +1 more source
PENGARUH PEMBELAJARAN DIRECT INSTRUCTION TERHADAP MINAT DAN KETERAMPILAN PASSING STOPPING PADA PEMBELAJARAN SEPAKBOLA ( Studi Eksperimen Di SMP Negeri 2 Kota Cirebon ) [PDF]
, 2014 Skripsi dilatarbelakangi oleh pentingnya pengaruh pembelajaran direct instruction terhadap minat dan keterampilan passing-stopping pada pembelajaran sepakbola di SMPN 2 Kota Cirebon.
Nuryadi, Rendi
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Model inovasi latihan meningkatkan keterampilan smash badminton
Multilateral: Jurnal Pendidikan Jasmani dan OlahragaPenelitian ini bertujuan untuk mengembangkan model inovasi pelatihan guna meningkatkan keterampilan smash dalam olahraga badminton melalui integrasi tiga pendekatan, yaitu Direct Instruction (DI), Practice Style (PS), dan Inclusion Style (IS).
Muhammad Rizky Putra Hadi, Mashud Mashud
doaj +1 more source