Results 1 to 10 of about 5,175,789 (337)

"Pseudo-Beijing": evidence for convergent evolution in the direct repeat region of Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2011
BackgroundMycobacterium tuberculosis has a global population structure consisting of six main phylogenetic lineages associated with specific geographic regions and human populations. One particular M.
Lukas Fenner, Bijaya Malla, Béatrice Ninet, Olivier Dubuis, David Stucki, Sonia Borrell, Thembela Huna, Thomas Bodmer, Matthias Egger, Sebastien Gagneux   +9 more
doaj   +5 more sources

CRISPRdigger: detecting CRISPRs with better direct repeat annotations. [PDF]

Sci Rep, 2016
Clustered regularly interspaced short palindromic repeats (CRISPRs) are important genetic elements in many bacterial and archaeal genomes, and play a key role in prokaryote immune systems’ fight against invasive foreign elements.
Ge R, Mai G, Wang P, Zhou M, Luo Y, Cai Y, Zhou F.   +6 more
europepmc   +6 more sources

Role of direct repeat and stem-loop motifs in mtDNA deletions: cause or coincidence? [PDF]

PLoS ONE, 2012
Deletion mutations within mitochondrial DNA (mtDNA) have been implicated in degenerative and aging related conditions, such as sarcopenia and neuro-degeneration. While the precise molecular mechanism of deletion formation in mtDNA is still not completely
Lakshmi Narayanan Lakshmanan, Jan Gruber, Barry Halliwell, Rudiyanto Gunawan   +3 more
doaj   +3 more sources

Preferential deletion events in the direct repeat locus of Mycobacterium tuberculosis. [PDF]

J Clin Microbiol, 2011
ABSTRACT The “Harlingen” IS 6110 restriction fragment length polymorphism (RFLP) cluster has linked over 100 tuberculosis cases in The Netherlands since 1993. Four Mycobacterium tuberculosis isolates that were epidemiologically linked to this cluster had different spoligotype ...
Schürch AC, Kremer K, Kiers A, Boeree MJ, Siezen RJ, van Soolingen D.   +5 more
europepmc   +8 more sources

A Genome-Wide Screen for Genes Affecting Spontaneous Direct-Repeat Recombination in Saccharomyces cerevisiae [PDF]

G3: Genes, Genomes, Genetics, 2020
Homologous recombination is an important mechanism for genome integrity maintenance, and several homologous recombination genes are mutated in various cancers and cancer-prone syndromes.
Daniele Novarina, Ridhdhi Desai, Jessica A. Vaisica, Jiongwen Ou, Mohammed Bellaoui, Grant W. Brown, Michael Chang   +6 more
doaj   +2 more sources

Structure and variation of CRISPR and CRISPR-flanking regions in deleted-direct repeat region Mycobacterium tuberculosis complex strains. [PDF]

BMC Genomics, 2017
BackgroundCRISPR and CRISPR-flanking genomic regions are important for molecular epidemiology of Mycobacterium tuberculosis complex (MTBC) strains, and potentially for adaptive immunity to phage and plasmid DNA, and endogenous roles in the bacterium ...
Freidlin PJ, Nissan I, Luria A, Goldblatt D, Schaffer L, Kaidar-Shwartz H, Chemtob D, Dveyrin Z, Head SR, Rorman E.   +9 more
europepmc   +2 more sources

Direct repeat-mediated DNA deletion of the mating type MAT1-2 genes results in unidirectional mating type switching in Sclerotinia trifoliorum. [PDF]

Sci Rep, 2016
The necrotrophic fungal pathogen Sclerotinia trifoliorum exhibits ascospore dimorphism and unidirectional mating type switching - self-fertile strains derived from large ascospores produce both self-fertile (large-spores) and self-sterile (small-spores ...
Xu L, Jardini TM, Chen W.
europepmc   +2 more sources

Epstein-Barr virus DNA. X. Direct repeat within the internal direct repeat of Epstein-Barr virus DNA [PDF]

Journal of Virology, 1981
The 3,360-base-pair internal direct repeat (IR) in Epstein-Barr virus DNA separates the short and long unique DNA domains. IR has a single BamHI site. The juncture between the short unique domain and IR has been mapped by restriction endonucleases and is less than 2,600 nucleotides before the BamHI site in IR.
Andrew Cheung, Elliott Kieff
openalex   +5 more sources

5′ DREDGE: Direct Repeat-Enabled Downregulation of Gene Expression via the 5′ UTR of Target Genes [PDF]

Cells
Despite the availability of numerous methods for controlling gene expression, there remains a strong need for technologies that maximize two key properties: selectivity and reversibility.
Sagar J. Parikh, Heather M. Terron, Luke A. Burgard, Dylan D. Butler, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring   +6 more
doaj   +2 more sources

Rosa26-GFP direct repeat (RaDR-GFP) mice reveal tissue- and age-dependence of homologous recombination in mammals in vivo. [PDF]

PLoS Genet, 2014
Homologous recombination (HR) is critical for the repair of double strand breaks and broken replication forks. Although HR is mostly error free, inherent or environmental conditions that either suppress or induce HR cause genomic instability. Despite its
Sukup-Jackson MR, Kiraly O, Kay JE, Na L, Rowland EA, Winther KE, Chow DN, Kimoto T, Matsuguchi T, Jonnalagadda VS, Maklakova VI, Singh VR, Wadduwage DN, Rajapakse J, So PT, Collier LS, Engelward BP.   +16 more
europepmc   +2 more sources