Results 101 to 110 of about 1,137,563 (252)

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Elongated polyproline motifs facilitate enamel evolution through matrix subunit compaction.

PLoS Biology, 2009
Vertebrate body designs rely on hydroxyapatite as the principal mineral component of relatively light-weight, articulated endoskeletons and sophisticated tooth-bearing jaws, facilitating rapid movement and efficient predation.
Tianquan Jin, Yoshihiro Ito, Xianghong Luan, Smit Dangaria, Cameron Walker, Michael Allen, Ashok Kulkarni, Carolyn Gibson, Richard Braatz, Xiubei Liao, Thomas G H Diekwisch   +10 more
doaj   +1 more source

Direct and accurate measurement of CAG repeat configuration in the ataxin-1 (ATXN-1) gene by “dual-fluorescence labeled PCR-restriction fragment length analysis” [PDF]

, 2008
Jiang X. Lin, Kinya Ishikawa, M Sakamoto, Taiji Tsunemi, Taro Ishiguro, Takeshi Amino, Shuta Toru, Ikuko Kondo, Hidehiro Mizusawa   +8 more
openalex   +1 more source

AC and AG Dinucleotide Repeats in the PAX6 P1 Promoter are Associated with High Myopia [PDF]

, 2011
Purpose: The PAX6 gene, located at the reported myopia locus MYP7 on chromosome 11p13, was postulated to be associated with myopia development. This study investigated the association of PAX6 with high myopia in 379 high myopia patients and 349 controls.
Chiang, Sylvia Wai Yee, Fan, Baojian, Fan, Dorothy Shu Ping, Lam, Ching Yan, Lam, Dennis Shun Chiu, Ng, Tsz Kin, Pang, Chi Pui, Tam, Pancy Oi Sin, Wang, Danyi, Yam, Gary Hin-Fai   +9 more
core  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Genome-Wide Tool for Sensitive de novo Identification and Visualisation of Interspersed and Tandem Repeats

Bioinformatics and Biology Insights
Genomic repeats are functionally ubiquitous structural units found in all genomes. Studying these repeats of different origins is essential for understanding the evolution and adaptation of a given organism.
Ruslan Kalendar, Ulykbek Kairov
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

The tandem direct repeats within the long terminal repeat of murine leukemia viruses are the primary determinant of their leukemogenic potential [PDF]

, 1984
Luc DesGroseillers, Paul Jolicoeur
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Prevalence and risk factors of repeat breeding in dairy cows in Cendana District, Enrekang Regency, South Sulawesi, Indonesia

Open Veterinary Journal
Background: Repeat breeding is a major reproductive disorder in dairy cows, resulting in extended calving intervals, increased insemination costs, and reduced milk production.
Kalvin N. Pongkapadang, Amrin Amrin, Rian Hari Suharto, Muhammad Yusuf, Erick Vitus Gabriel Komba, John King N. Layos, Fika Yuliza Purba, Subaedy Yusuf   +7 more
doaj   +1 more source