Results 111 to 120 of about 1,651,751 (370)

ZNF9 activation of IRES-mediated translation of the human ODC mRNA is decreased in myotonic dystrophy type 2. [PDF]

PLoS ONE, 2010
Myotonic dystrophy types 1 and 2 (DM1 and DM2) are forms of muscular dystrophy that share similar clinical and molecular manifestations, such as myotonia, muscle weakness, cardiac anomalies, cataracts, and the presence of defined RNA-containing foci in ...
Morgan A Sammons, Amanda K Antons, Mourad Bendjennat, Bjarne Udd, Ralf Krahe, Andrew J Link   +5 more
doaj   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1

Disease Models & Mechanisms, 2014
Myotonic dystrophy type I (DM1) is a multi-system, autosomal dominant disorder caused by expansion of a CTG repeat sequence in the 3′UTR of the DMPK gene.
Peter K. Todd, Feras Y. Ackall, Junguk Hur, Kush Sharma, Henry L. Paulson, James J. Dowling   +5 more
doaj   +1 more source

Engineered DNA-encoded monoclonal antibodies targeting Plasmodium falciparum circumsporozoite protein confer single dose protection in a murine malaria challenge model

Scientific Reports, 2022
Novel approaches for malaria prophylaxis remain important. Synthetic DNA-encoded monoclonal antibodies (DMAbs) are a promising approach to generate rapid, direct in vivo host-generated mAbs with potential benefits in production simplicity and ...
Nicholas J. Tursi, Sophia M. Reeder, Yevel Flores-Garcia, Mamadou A. Bah, Shamika Mathis-Torres, Berenice Salgado-Jimenez, Rianne Esquivel, Ziyang Xu, Jacqueline D. Chu, Laurent Humeau, Ami Patel, Fidel Zavala, David B. Weiner   +12 more
doaj   +1 more source

Applications of Repeated Games in Wireless Networks: A Survey [PDF]

arXiv, 2015
A repeated game is an effective tool to model interactions and conflicts for players aiming to achieve their objectives in a long-term basis. Contrary to static noncooperative games that model an interaction among players in only one period, in repeated games, interactions of players repeat for multiple periods; and thus the players become aware of ...
arxiv  

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Neurons Induced From Fibroblasts of c9ALS/FTD Patients Reproduce the Pathology Seen in the Central Nervous System

Frontiers in Neuroscience, 2019
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are incurable neurodegenerative conditions. A non-coding hexanucleotide (GGGGCC) repeat expansion in the c9orf72 gene is the most common genetic cause of ALS/FTD. We present a cellular
Peter O. Bauer, Peter O. Bauer, Peter O. Bauer, Judith H. Dunmore, Hiroki Sasaguri, Vaclav Matoska   +5 more
doaj   +1 more source

The Physics of Disk Winds, Jets,and X-ray Variability in GRS 1915+105 [PDF]

, 2010
We present new insights about accretion and ejection physics based on joint RXTE/Chandra HETGS studies of rapid X-ray variability in GRS 1915+105. For the first time, with fast phase-resolved spectroscopy of the rho state, we are able to show that ...
Belloni, Hannikainen, Joseph Neilsen, Julia C. Lee, Mirabel, Ron Remillard   +5 more
core   +1 more source

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source

The Role of the MRX Complex and the Non-homologous End Joining DNA Repair Pathway in Mitochondrial Genome Stability and Repair [PDF]

, 2009
Mitochondria are required for cellular respiration, which is essential in the production of ATP. Mitochondrial genome maintenance is necessary for the continued function of the mitochondrion. Deletions within the mitochondrial DNA (mtDNA) have been shown
Coles, Garry L.
core   +1 more source