Results 121 to 130 of about 1,569,399 (342)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Genome-Wide Tool for Sensitive de novo Identification and Visualisation of Interspersed and Tandem Repeats

Bioinformatics and Biology Insights
Genomic repeats are functionally ubiquitous structural units found in all genomes. Studying these repeats of different origins is essential for understanding the evolution and adaptation of a given organism.
Ruslan Kalendar, Ulykbek Kairov
doaj   +1 more source

Non-coding RNA in C9orf72-related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction

Non-coding RNA Research, 2018
A hexanucleotide repeat expansion in the first intron/promoter region of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Andrew G.L. Douglas
doaj   +1 more source

Copy mutant of mini-Rts1: lowered binding affinity of mutated RepA protein to direct repeats [PDF]

, 1985
Y Terawaki, Yoshifumi Itoh
openalex   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

AC and AG Dinucleotide Repeats in the PAX6 P1 Promoter are Associated with High Myopia [PDF]

, 2011
Purpose: The PAX6 gene, located at the reported myopia locus MYP7 on chromosome 11p13, was postulated to be associated with myopia development. This study investigated the association of PAX6 with high myopia in 379 high myopia patients and 349 controls.
Chiang, Sylvia Wai Yee, Fan, Baojian, Fan, Dorothy Shu Ping, Lam, Ching Yan, Lam, Dennis Shun Chiu, Ng, Tsz Kin, Pang, Chi Pui, Tam, Pancy Oi Sin, Wang, Danyi, Yam, Gary Hin-Fai   +9 more
core  

The tandem direct repeats within the long terminal repeat of murine leukemia viruses are the primary determinant of their leukemogenic potential [PDF]

, 1984
Luc DesGroseillers, Paul Jolicoeur
openalex   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Prevalence and risk factors of repeat breeding in dairy cows in Cendana District, Enrekang Regency, South Sulawesi, Indonesia

Open Veterinary Journal
Background: Repeat breeding is a major reproductive disorder in dairy cows, resulting in extended calving intervals, increased insemination costs, and reduced milk production.
Kalvin N. Pongkapadang, Amrin Amrin, Rian Hari Suharto, Muhammad Yusuf, Erick Vitus Gabriel Komba, John King N. Layos, Fika Yuliza Purba, Subaedy Yusuf   +7 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source