Precise sequence complementarity between yeast chromosome ends and two classes of just-subtelomeric sequences [PDF]
The terminal regions (last 20 kb) of Saccharomyces cerevisiae chromosomes universally contain blocks of precise sequence similarity to other chromosome terminal regions.
Britten, Roy J.
core +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Transfer origins in the conjugative Enterococcus faecalis plasmids pAD1 and pAM373: identification of the pAD1 nic site, a specific relaxase and a possible TraG-like protein [PDF]
The Enterococcus faecalis conjugative plasmids pAD1 and pAM373 encode a mating response to the peptide sex pheromones cAD1 and cAM373 respectively. Sequence determination of both plasmids has recently been completed with strong similarity evident over ...
Arthur M.+61 more
core +1 more source
Autophagy in cancer and protein conformational disorders
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Factors affecting double-strand break-induced homologous recombination in mammalian cells
Double-strand break (DSB)-induced homologous recombination (HR) of direct repeats is a powerful means to achieve gene excision, a critical step in genome engineering.
Christophe Perez+8 more
doaj +1 more source
Bayesian neural network learning for repeat purchase modelling in direct marketing. [PDF]
We focus on purchase incidence modelling for a European direct mail company. Response models based on statistical and neural network techniques are contrasted.
Baesens, Bart+4 more
core
Air investigation of some alternative methods to agrobacterium and protoplast transformation for introducing exogenous genes into plants, based on the use of pollen as a vector [PDF]
Some of the problems involved in the search for alternative plant transformation vectors have been examined. In particular the use of pregerminated pollen as a direct transformation vector has been investigated.
Morris, S.R.
core
Binding of PhoP to promoters of phosphate‐regulated genes in Streptomyces coelicolor: identification of PHO boxes [PDF]
[EN] The control of phosphate-regulated genes in Streptomyces coelicolor is mediated by the two-component system PhoR–PhoP. When coupled to the reporter xylE gene the pstS, phoRP and phoU promoters were shown to be very sensitive to phosphate regulation.
Franco Domínguez, Etelvina+3 more
core +1 more source
Direct Observation of Parallel Folding Pathways Revealed Using a Symmetric Repeat Protein System [PDF]
Although progress has been made to determine the native fold of a polypeptide from its primary structure, the diversity of pathways that connect the unfolded and folded states has not been adequately explored.
Aksel, Tural, Barrick, Doug
core +1 more source
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens+8 more
wiley +1 more source