Results 11 to 20 of about 1,569,399 (342)

A human CAGinSTEM platform for decoding HTT repeats’ somatic instability links CAG interruption to HD pathology in neurons

Cell Reports
Summary: Somatic CAG instability in the mutant Huntingtin (HTT) gene is increasingly recognized as a key hallmark of Huntington’s disease (HD). Using our novel human CAGinSTEM platform, we manipulated cis genetic elements influencing instability in human
Martina Zobel, Gianluca Damaggio, Maria Lidia Mignogna, Dario Besusso, Davide Scalzo, Andrea Cossu, Camilla Trovesi, Mariacristina Crosti, Francesco Cortina, Ilaria Campus, Giulio Formenti, Saveria Mazzara, Francesco Gregoretti, Laura Antonelli, Gennaro Oliva, Chiara Zuccato, Vincenza Colonna, Paola Conforti, Matteo Cereda, Riccardo Lorenzo Rossi, Simone Maestri, Andrea Scolz, Raffale Iennaco, Elena Cattaneo   +23 more
doaj   +2 more sources

Direct repeats [PDF]

Nature, 1990
Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/62823/1/345584a0 ...
Koenig, R. J., Brent, G. A., Larsen, P. Reed, Moore, D. D.   +3 more
openaire   +3 more sources

Studies on ultrasound-mediated insertion-deletion polymorphisms of DNA and underlying mechanisms based on Ames tester strains

Ultrasonics Sonochemistry, 2023
Low-lethality ultrasound technology has received more and more attention in regulating microorganisms of fermentation industry. Herein, two representative Ames tester strains TA97a and TA98 as model organisms were used to explore the effects of ...
Yunliang Li, Siyu Ruan, Feng Lu, Pengfei Xie, Xiaoshuang Liu, Haile Ma   +5 more
doaj   +1 more source

Accurate contact-based modelling of repeat proteins predicts the structure of new repeats protein families.

PLoS Computational Biology, 2021
Repeat proteins are abundant in eukaryotic proteomes. They are involved in many eukaryotic specific functions, including signalling. For many of these proteins, the structure is not known, as they are difficult to crystallise.
Claudio Bassot, Arne Elofsson
doaj   +1 more source

Direct observation of repeated infections with endemic coronaviruses [PDF]

The Journal of Infectious Diseases, 2020
AbstractBackgroundWhile the mechanisms of adaptive immunity to pandemic coronavirus SARS-CoV-2 are still unknown, the immune response to the widespread endemic coronaviruses HKU1, 229E, NL63 and OC43 provide a useful reference for understanding repeat infection risk.MethodsHere we used data from proactive sampling carried out in New York City from fall
Galanti, Marta, Shaman, Jeffrey
openaire   +2 more sources

A novel technique for measuring the reflection coefficient of sound absorbing materials [PDF]

, 2000
A new method to measure the acoustic behaviour of sound absorbing material in an impedance tube is presented. The method makes use of a novel particle velocity sensor, the microflown, and a microphone.
Bree, H-E. de, Eerden, F.J.M. van der, Honschoten, J.W. van   +2 more
core   +11 more sources

Repeat Diagnoses of Bethesda Category III Thyroid Nodules: What To Do Next? [PDF]

PLoS ONE, 2015
To assess the malignancy rates of thyroid nodules repeatedly classified as Bethesda category III on fine needle aspiration (FNA), and to suggest management guidelines for these lesions.This is a retrospective study that included 395 thyroid nodules ...
Mi Ri Yoo, Hye Mi Gweon, Ah Young Park, Kyung Eun Cho, Jeong-Ah Kim, Ji Hyun Youk, Eun Ju Son   +6 more
doaj   +1 more source

CAG Repeat Instability in the Peripheral and Central Nervous System of Transgenic Huntington’s Disease Monkeys

Biomedicines, 2022
Huntington’s Disease (HD) is an autosomal dominant disease that results in severe neurodegeneration with no cure. HD is caused by the expanded CAG trinucleotide repeat (TNR) on the Huntingtin gene (HTT). Although the somatic and germline expansion of the
In K. Cho, Faye Clever, Gordon Hong, Anthony W. S. Chan   +3 more
doaj   +1 more source

CrisprVi: a software for visualizing and analyzing CRISPR sequences of prokaryotes

BMC Bioinformatics, 2022
Background Clustered regularly interspaced short palindromic repeats (CRISPR) and their spacers are important components of prokaryotic CRISPR-Cas systems.
Lei Sun, Jinbiao Wang, Fu Yan, Gongming Wang, Yun Li, Jinlin Huang   +5 more
doaj   +1 more source

Directed Repeats Co-occur with Few Short-Dispersed Repeats in Plastid Genome of a Spikemoss, Selaginella vardei (Selaginellaceae, Lycopodiopsida)

BMC Genomics, 2019
Background It is hypothesized that the highly conserved inverted repeats (IR) structure of land plant plastid genomes (plastomes) is beneficial for stabilizing plastome organization, whereas the mechanism of the occurrence and stability maintenance of ...
Hong-Rui Zhang, Xian-Chun Zhang, Qiao-Ping Xiang   +2 more
doaj   +1 more source