Results 211 to 220 of about 5,175,789 (337)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Two-Step Recruitment of RNA-Directed DNA Methylation to Tandem Repeats

, 2006
Wan Chan, Xiaoyu Zhang, Yana V. Bernatavichute, Steven E. Jacobsen   +3 more
openalex   +2 more sources

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Array Assembler Provides Greatly Simplified crRNA Array Design for CRISPR Cas12 and Cas13 Variants. [PDF]

ACS Synth Biol
Bryson JW.
europepmc   +1 more source

The Basic Domain of TRF2 Directs Binding to DNA Junctions Irrespective of the Presence of TTAGGG Repeats

, 2006
Nicole Fouché, Anthony J. Cesare, Smaranda Willcox, Sezgin Özgür, Sarah A. Compton, Jack D. Griffith   +5 more
openalex   +1 more source

Retraction for Leung et al., Direct Interaction between the WD40 Repeat Protein WDR-23 and SKN-1/Nrf Inhibits Binding to Target DNA [PDF]

, 2015
Chi K. Leung, Koichi Hasegawa, Ying Wang, Andrew Deonarine, Lanlan Tang, Johji Miwa, Keith Choe   +6 more
openalex   +1 more source

Direct repeat sequences are implicated in the regulation of two Streptomyces chitinase promoters that are subject to carbon catabolite control.

Proceedings of the National Academy of Sciences of the United States of America, 1992
Ina Delic, Phillips W. Robbinst, Janet Westpheling   +2 more
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Evolutionary trends in <i>Bombella apis</i> CRISPR-Cas systems. [PDF]

mSystems
Ganote CL, Caesar L, Rice DW, Whitaker RJ, Newton ILG.   +4 more
europepmc   +1 more source

Direct repeats in the flavivirus 3′ untranslated region; a strategy for survival in the environment?

, 2006
Т.С. Грицун, Ernest A. Gould
openalex   +1 more source