Results 291 to 300 of about 1,651,751 (370)

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

TIGR-Tas: A family of modular RNA-guided DNA-targeting systems in prokaryotes and their viruses. [PDF]

Science
Faure G, Saito M, Wilkinson ME, Quinones-Olvera N, Xu P, Flam-Shepherd D, Kim S, Reddy N, Zhu S, Evgeniou L, Koonin EV, Macrae RK, Zhang F.   +12 more
europepmc   +1 more source

In theStaphylococcus aureusTwo-Component Systemsae, the Response Regulator SaeR Binds to a Direct Repeat Sequence and DNA Binding Requires Phosphorylation by the Sensor Kinase SaeS

, 2010
Fei Sun, Chunling Li, Do‐Won Jeong, Changmo Sohn, Chuan He, Taeok Bae   +5 more
openalex   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

FEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel, Rachel Brown, Alexa Rabeling, Mubeen Goolam   +3 more
wiley   +1 more source

Genome-wide maps of highly-similar intrachromosomal repeats that can mediate ectopic recombination in three human genome assemblies. [PDF]

HGG Adv
Fernandez-Luna L, Aguilar-Perez C, Grochowski CM, Mehaffey MG, Carvalho CMB, Gonzaga-Jauregui C.   +5 more
europepmc   +1 more source

Mitochondrial DNA, direct repeats, deletions, and centenarians: An unfinished puzzle

, 2010
Xinhong Guo, Igor Dombrovsky, Tanya Leibman, Yevgenya Kraytsberg, Konstantin Popadin, Konstantin Khrapko   +5 more
openalex   +1 more source

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Andexanet alfa for reversal of intracerebral haemorrhage resulting in ST-segment myocardial infarction: a case report. [PDF]

Eur Heart J Case Rep
Mehrara S, Patel R, DeRon N.
europepmc   +1 more source

The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise

FEBS Open Bio, EarlyView.
Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji, Hae Sung Lee, Haesung Lee, Jong‐Hee Kim   +3 more
wiley   +1 more source

The distribution of D4Z4 repeats in China and direct prenatal diagnosis of FSHD by optical genome mapping. [PDF]

Orphanet J Rare Dis
Li M, Hao N, Chang J, Yin K, Yang X, Wang Y, Dai Y, Jiang Y.   +7 more
europepmc   +1 more source