Results 61 to 70 of about 1,471,677 (345)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Nucleotide repeats in mitochondrial genome determine human lifespan [PDF]
, 2008 Direct nucleotide repeats can facilitate deletions of segments of mitochondrial genome1, leading to a wide range of neuromuscular disorders1,2 as well as aging2,3 in humans.
Georgii Bazykin, Konstantin Popadin
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
G3: Genes, Genomes, Genetics, 2019 Candida albicans, the most common fungal pathogen, is a diploid with a genome that is rich in repeats and has high levels of heterozygosity. To study the role of different recombination pathways on direct-repeat recombination, we replaced either allele ...
Alberto Bellido +5 more
doaj +1 more source
DMSO Improves the Ski-Slope Effect in Direct PCR
Applied Sciences, 2021 Analytical techniques such as DNA profiling are widely used in various fields, including forensic science, and novel technologies such as direct polymerase chain reaction (PCR) amplification are continuously being developed in order to acquire DNA ...
Joo-Young Kim +6 more
doaj +1 more source
RecA-independent recombination between direct repeats of IS50
Cell, 1983 Recombination between the IS50 sequences that flank Tn5 has been found to occur readily after the transformation of E. coli recA strains with a plasmid that contains direct repeats of these sequences. Analysis of mutants of IS50 indicates that the polypeptide encoded by IS50 that is required for transposition is also required for the recombination ...
T. J. Zupancic +4 more
openaire +3 more sources
Peripheral Muscle Function During Repeated Changes of Direction in Basketball [PDF]
International Journal of Sports Physiology and Performance, 2019 Purpose: To examine differences between adult male basketball players of different competitive levels (study 1) and changes over a basketball season (study 2) of knee-extensor peripheral muscle function during multistage change-of-direction exercise (MCODE).
Ferioli, Davide +4 more
openaire +3 more sources
Motivational Factors Behind Repetitive Abortions [PDF]
, 1977 This practicum intends to explore the motivational factors behind repeat abortions. The underlying assumptions of this study include: (1) women have abortions; (2) women have repeat abortions. Based on these assumptions, the two research questions are (1)
Osmont, Kelly, Wolfford, Ellen
core +1 more source
The Physics of Disk Winds, Jets,and X-ray Variability in GRS 1915+105 [PDF]
, 2010 We present new insights about accretion and ejection physics based on joint RXTE/Chandra HETGS studies of rapid X-ray variability in GRS 1915+105. For the first time, with fast phase-resolved spectroscopy of the rho state, we are able to show that ...
Belloni +5 more
core +1 more source
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source