Results 61 to 70 of about 1,651,751 (370)
A Direct Repeat Sequence at theRasgrf1Locus and Imprinted Expression
Genomics, 1999 Genomic imprinting is an epigenetic modification that can lead to parental-specific monoallelic expression of specific autosomal genes. While methylation of CpG dinucleotides is thought to be a strong candidate for this epigenetic modification, little is known about the establishment or maintenance of parental origin-specific methylation patterns.
Christoph Plass +6 more
openaire +2 more sources
Fate of direct and inverted repeats in the RNA hypermutagenesis reaction [PDF]
Nucleic Acids Research, 1996 RNA hypermutagenesis results from cDNA synthesis in the presence of highly biased dNTP precursor concentrations and preferentially exploits human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Such reaction conditions slow down DNA synthesis, which might be conducive to strand transfer and deletion. This has been investigated.
Valérie Pezo +2 more
openaire +3 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Direct and Inverted Repeat stimulated excision (DIRex): Simple, single-step, and scar-free mutagenesis of bacterial genes. [PDF]
PLoS ONE, 2017 The need for generating precisely designed mutations is common in genetics, biochemistry, and molecular biology. Here, I describe a new λ Red recombineering method (Direct and Inverted Repeat stimulated excision; DIRex) for fast and easy generation of ...
Joakim Näsvall
doaj +1 more source
Intramolecular integration within Moloney murine leukemia virus DNA [PDF]
, 1981 By screening a library of unintegrated, circular Moloney murine leukemia virus (M-MuLV) DNA cloned in lambda phage, we found that approximately 20% of the M-MuLV DNA inserts contained internal sequence deletions or inversions.
Baltimore, David +3 more
core
Temporally multiplexed quantum repeaters with atomic gases [PDF]
Phys. Rev. A 82, 010304(R) (2010), 2010 We propose a temporally multiplexed version of the Duan-Lukin-Cirac-Zoller (DLCZ) quantum repeater protocol using controlled inhomogeneous spin broadening in atomic gases. A first analysis suggests that the advantage of multiplexing is negated by noise due to spin wave excitations corresponding to unobserved directions of Stokes photon emission ...
arxiv +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
African Journal of Primary Health Care & Family Medicine, 2018 Background: Adolescent repeat pregnancy is of importance in public health because the birth of a second child to an adolescent mother compounds the adverse medical, educational, socioeconomic and parenting outcomes. Repeat pregnancy in adolescence is not
Desiree Govender +2 more
doaj +1 more source
Evolutionary dynamics in repeated optional games [PDF]
arXiv, 2022 Direct reciprocity facilitates the evolution of cooperation when individuals interact repeatedly. Most previous studies on direct reciprocity implicitly assume compulsory interactions. Yet, interactions are often voluntary in human societies. Here, we consider repeated optional games, where individuals can freely opt out of each interaction and rejoin ...
arxiv
Short, direct repeats at the breakpoints of deletions of the retinoblastoma gene. [PDF]
Proceedings of the National Academy of Sciences, 1989 We found deletions involving the retinoblastoma gene in 12 of 49 tumors from patients with retinoblastoma or osteosarcoma. After mapping the deletion breakpoints, we found that no two breakpoints coincided. Thus, our data do not support the conclusions of others regarding the existence of a "hotspot" for deletion breakpoints in this gene.
Thaddeus P. Dryja, Susan Canning
openaire +3 more sources