Results 71 to 80 of about 1,137,563 (252)

Estimating changes in ocean ventilation from early 1990s CFC-12 and late 2000s SF6 measurements [PDF]

, 2013
Transient tracer measurements can constrain the rates and pathways of ocean ventilation and act as proxies for biogeochemically relevant gases such as CO2 and oxygen.
Bindoff, Bryan, Bullister, Bullister, Darryn W. Waugh, DeVries, Fine, Freing, Gammon, Haine, Hall, John L. Bullister, Law, McDonagh, McPhaden, Mecking, Mecking, Rhein, Sonnerup, Sonnerup, Steinfeldt, Tanhua, Tanhua, Tanhua, Toste Tanhua, Walker, Warner, Waugh, Waugh, Waugh, Zhang, Álvarez   +31 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Leading role of TBP in the Establishment of Complexity in Eukaryotic Transcription Initiation Systems

Cell Reports, 2017
While both archaeal and eukaryotic transcription initiation systems utilize TBP (TATA box-binding protein) and TFIIB (transcription factor IIB), eukaryotic systems include larger numbers of initiation factors.
Eiryo Kawakami, Naruhiko Adachi, Toshiya Senda, Masami Horikoshi   +3 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)

BMC Genetics, 2005
Background The 10-repeat allele of a variable number tandem repeat (VNTR) polymorphism in the 3'-untranslated region of the dopamine transporter gene (DAT1) has been associated with a range of psychiatric phenotypes, most notably attention-deficit ...
D'Souza Ursula M, Craig Ian, Asherson Philip, Mill Jonathan   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Transcriptional changes and developmental abnormalities in a zebrafish model of myotonic dystrophy type 1

Disease Models & Mechanisms, 2014
Myotonic dystrophy type I (DM1) is a multi-system, autosomal dominant disorder caused by expansion of a CTG repeat sequence in the 3′UTR of the DMPK gene.
Peter K. Todd, Feras Y. Ackall, Junguk Hur, Kush Sharma, Henry L. Paulson, James J. Dowling   +5 more
doaj   +1 more source

Sequence diversity and molecular evolution of the merozoite surface antigen 2 of plasmodium falciparum [PDF]

, 2018
Eleven new alleles of the Plasmodium falciparum merozoite surface antigen 2 (MSA2) from Papua New Guinea were analyzed by direct sequencing of polymerase chain reaction (PCR) products.
Beck, Hans-Peter, Felger, Ingrid, Hunt, John, Marshal, Vikki, Mgone, Charles, Reeder, John   +5 more
core  

C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease, characterised by progressive failure of the neuromuscular system.
Adrian Higginbottom, Adriano Chio, Alan E. Renton, Almeida, Andrea Calvo, Ash, Atanasio, Beer, Belzil, Benjamini, Breitling, Bryan J. Traynor, Burberry, Byrne, Chew, Ciura, Cooper-Knock, Cooper-Knock, Cooper-Knock, Cooper-Knock, Davidson, DeJesus-Hernandez, Donnelly, Gendron, Gomez-Deza, Guillaume M. Hautbergue, Haeusler, Hannah Pliner, Janine Kirby, Jiang, Johnathan Cooper-Knock, Kirby, Koppers, Kurt J. De Vos, Kwon, Lagier-Tourenne, Lee, Little, Liu, Mackenzie, Mackenzie, Matthew J. Stopford, May, Milella, Mimoun Azzouz, Mizielinska, Mori, Mori, Mori, Nalls, Ning, O'Rourke, O'Rourke, Padraig J. Mulcahy, Pamela J. Shaw, Paul R. Heath, Pearson, Peters, Prudencio, Purcell, Rattray, Renoux, Renton, Sareen, Smedley, Sudria-Lopez, Sullivan, Tao, Therrien, Tran, Waite, Webster, Wen, Xiao, Xu, Yang, Yang, Zhang, Zu   +78 more
core   +3 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source