Results 91 to 100 of about 11,830,288 (332)

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning

Cell, 2020
SUMMARY Serotonin plays a central role in cognition and is the target of most pharmaceuticals for psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will require better understanding of serotonergic circuitry ...
Elizabeth K. Unger, J. Keller, Michael Altermatt, Ru-Qiang Liang, A. Matsui, Chun-Yang Dong, Olivia J. Hon, Zi Yao, Jun-Qing Sun, Sambashiva Banala, Meghan E. Flanigan, David A. Jaffe, S. Hartanto, Jane Carlen, G. Mizuno, Phillip M. Borden, Amol V. Shivange, Lindsay P. Cameron, Steffen Sinning, S. Underhill, D. E. Olson, S. Amara, Duncan Temple Lang, Gary Rudnick, J. Marvin, Luke D. Lavis, Henry A. Lester, Veronica A. Alvarez, Andrew J. Fisher, Jennifer A. Prescher, T. Kash, Vladimir Yarov-Yarovoy, Viviana Gradinaru, L. Looger, Lin Tian   +34 more
semanticscholar   +1 more source

Behavioral Phylogenies and the Direction of Evolution

Science, 1983
A model for using mate preference data to deduce the direction of evolution between populations related by founder events or population bottlenecks is examined. Data from a wide range of organisms satisfying the necessary constraints of population structure are compatible with the model developed by K. Y. Kaneshiro from studies of Hawaiian
L V, Giddings, A R, Templeton
openaire   +2 more sources

Directed evolution unlocks oxygen reactivity for a nicotine degrading flavoenzyme

, 2023
Data included in the publication "Directed evolution unlocks oxygen reactivity for a nicotine degrading flavoenzyme"
Mark Dulchavsky (16502424)
core   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Eukaryotic-driven directed evolution of Cas9 nucleases

Genome Biology
Background Further advancement of genome editing highly depends on the development of tools with higher compatibility with eukaryotes. A multitude of described Cas9s have great potential but require optimization for genome editing purposes.
Giulia Vittoria Ruta, Matteo Ciciani, Eyemen Kheir, Michele Domenico Gentile, Simone Amistadi, Antonio Casini, Anna Cereseto   +6 more
doaj   +1 more source

Directed evolution of the optoelectronic properties of synthetic nanomaterials [PDF]

, 2019
Directed evolution is a powerful approach to tailor protein properties toward new or enhanced functions. Herein, we use directed evolution to engineer the optoelectronic properties of DNA-wrapped single-walled carbon nanotube sensors through DNA mutation.
Wu, Shang-Jung, Boghossian, Ardemis A., Schuergers, Nils, Lambert, Benjamin, Gillen, Alice J., Boghossian AA, Lambert B, Wu SJ, Gillen AJ, Schuergers N   +9 more
core   +1 more source

Referral Patterns and Diagnostic Timeliness in Pediatric Cancer: A Hospital‐Based Study in Indonesia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Timely diagnosis and treatment are critical for improving survival among children with cancer. In low‐ and middle‐income countries (LMICs), delays are common and may be influenced by fragmented referral pathways and diagnostic limitations.
Nur Melani Sari, Regina Hadi Putri, Fatimah Assyifa, Judith Spijkerman, Gertjan Johannes Kaspers, Susi Susanah   +5 more
wiley   +1 more source

Comprehensive Analysis of Allulose Production: A Review and Update

Foods
Advancements in D-allulose production have seen significant strides in recent years, focusing on enzymatic conversion methods. Key developments include traditional immobilization techniques, the discovery of novel enzymes, directed evolution studies, and
Lei Wang, Yun Cui, Yujie Lu, Zongpei Zhao   +3 more
doaj   +1 more source