Results 71 to 80 of about 1,378,774 (287)

Directing the evolution of Rubisco and Rubisco activase: first impressions of a new tool for photosynthesis research [PDF]

, 2008
During the last decade the practice of laboratory-directed protein evolution has become firmly established as a versatile tool in biochemical research by enabling molecular evolution toward desirable phenotypes or detection of novel structure-function ...
Oliver Mueller-Cajar, Spencer M. Whitney, A Aharoni, I Andersson, TJ Andrews, TJ Andrews, FH Arnold, FH Arnold, FH Arnold, FH Arnold, H Ashida, H Ashida, G Bainbridge, S Bershtein, LA Castle, Z Chen, LP Cloney, SJ Crafts-Brandner, A Crameri, AM Dean, DA Drummond, YC Du, D Emlyn-Jones, J Gewolb, DN Greene, AD Griffiths, LM Guzman, TE Hanson, GS Hudson, TW Johannes, K Kim, I Kurek, HN Lin, SP Long, M Ludwig, CC Mann, I Matsumura, J Maynard Smith, OJ Miller, MK Morell, O Mueller-Cajar, C Neylon, WL Ogren, GC Paoli, MR Parikh, MR Parikh, MAJ Parry, MAJ Parry, SG Peisajovich, J Pierce, FJ Poelwijk, AR Portis, C Roodveldt, ME Salvucci, ME Salvucci, ME Salvucci, S Saschenbrecker, C Schmidt-Dannert, TD Sharkey, SA Smith, CR Somerville, CR Somerville, RJ Spreitzer, RJ Spreitzer, RJ Spreitzer, RJ Spreitzer, WPC Stemmer, GB Tcherkez, G Thow, CA Voigt, GS Waldo, GMF Watson, SM Whitney, SM Whitney, A Wingler, KJ Woycechowsky, Y Yoshikuni, L Yuan, XG Zhu   +78 more
core   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Analytical study of the effect of recombination on evolution via DNA shuffling

, 2003
We investigate a multi-locus evolutionary model which is based on the DNA shuffling protocol widely applied in \textit{in vitro} directed evolution. This model incorporates selection, recombination and point mutations.
A. S. Kondrashov, D. A. Kessler, D. S. Falconer, E. E. Shnol, F. Sun, H. Lodish, H. Mühlenbein, H.-G. Beyer, J. F. Crow, L. Chao, M. Barlow, M. Kimura, N. H. Barton, P. H. Von Hippel, R. Büger, R. J. Redfield, S. P. Otto, S. P. Otto, W. P. C. Stemmer   +18 more
core   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Directed evolution of nucleotide-based libraries using lambda exonuclease

BioTechniques, 2012
Directed evolution of nucleotide libraries using recombination or mutagenesis is an important technique for customizing catalytic or biophysical traits of proteins.
Bee Nar Lim, Yee Siew Choong, Asma Ismail, Jörn Glökler, Zoltán Konthur, Theam Soon Lim   +5 more
doaj   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Theory of Interface: Category Theory, Directed Networks and Evolution of Biological Networks [PDF]

, 2012
Biological networks have two modes. The first mode is static: a network is a passage on which something flows. The second mode is dynamic: a network is a pattern constructed by gluing functions of entities constituting the network.
Haruna, Taichi
core  

Blinatumomab Utilization in Pediatric B‐Cell Acute Lymphoblastic Leukemia: Experience From the Mountain West

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Blinatumomab is a bispecific T‐cell engager approved for the treatment of pediatric B‐cell acute lymphoblastic leukemia (B‐ALL). Outpatient home infusion reduces hospitalization burden and optimizes resource utilization, but is logistically challenging.
Angela Parra del Riego, Kellee Parker, William C. Thomsen, James B. Ford, Mallorie B. Heneghan, David Spencer Mangum, Jennifer L. McNeer, Luke D. Maese, Claire E. F. Miller, Richard Lemons, Taumoha Ghosh   +10 more
wiley   +1 more source

Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris [PDF]

, 2000
The ability to engineer proteins by directed evolution requires functional expression of the target polypeptide in a recombinant host suitable for construction and screening libraries of enzyme variants.
Arnold, Frances H., Bandara, Geethani, Cirino, Pat, Joo, Hyun, Lin, Zhanglin, Morawski, Birgit   +5 more
core  

Monte Carlo simulation of boson lattices

, 2006
Boson lattices are theoretically well described by the Hubbard model. The basic model and its variants can be effectively simulated using Monte Carlo techniques.
Nightingale M. P., OLAV F. SYLJUÅSEN, VESA APAJA   +2 more
core   +1 more source