Results 71 to 80 of about 11,830,288 (332)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Directed evolution strategies for improved enzymatic performance
Microbial Cell Factories, 2005 The engineering of enzymes with altered activity, specificity and stability, using directed evolution techniques that mimic evolution on a laboratory timescale, is now well established.
Dalby Paul A, Hibbert Edward G
doaj +1 more source
Directed Chemical Evolution with an Outsized Genetic Code. [PDF]
PLoS ONE, 2016 The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark +3 more
doaj +1 more source
Directing Drug Evolution [PDF]
BioTechniques, 2017 Directed evolution is poised to change small molecule discovery and provide greater access to “drug space.” Sarah Webb looks into the evolving drug discovery landscape.
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Directed evolution of transketolase, a carbon-carbon forming enzyme. [PDF]
, 2005 The enzyme transketolase (Enzyme Commission number: 2.2.1.1) has significant potential as a biocatalyst in the production of pharmaceuticals and fine chemicals.
Miller, O.J.
core
Directed Evolution of Protoglobin Optimizes the Enzyme Electric Field [PDF]
To unravel why computational design fails in creating viable enzymes, while directed evolution (DE) succeeds, our research delves into the laboratory evolution of Protoglobin. DE has adapted this protein to efficiently catalyze carbene transfer reactions.
Santiago, Vargas +3 more
core +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom +15 more
wiley +1 more source
Towards the Directed Evolution of Hybrid Catalysts
CHIMIA, 2002 The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and ...
Manfred T. Reetz +3 more
doaj +1 more source
Design and directed evolution of noncanonical β-stereoselective metalloglycosidases
Nature Communications, 2022 Metallohydrolases are ubiquitous enzymes. Here the authors show the design and biochemical characterisation of metalloglycosidase by constructing a hydrolytically active Zn-binding site within a barrel-shaped outer membrane protein OmpF.
Woo Jae Jeong, Woon Ju Song
doaj +1 more source