Results 51 to 60 of about 286,859 (297)

Directed Chemical Evolution with an Outsized Genetic Code. [PDF]

PLoS ONE, 2016
The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark, Nicolas P Tilmans, Patrick O Brown, Pehr B Harbury   +3 more
doaj   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Oncolytic Viruses: The Power of Directed Evolution

Advances in Virology, 2012
Attempts at developing oncolytic viruses have been primarily based on rational design. However, this approach has been met with limited success. An alternative approach employs directed evolution as a means of producing highly selective and potent ...
Maxine Bauzon, Terry W. Hermiston
doaj   +1 more source

Venous Thromboembolism in Pediatric Bone Sarcoma Patients: A 10‐Year, Single‐Institution Experience Encompassing the COVID‐19 Pandemic

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteosarcoma (OS) and Ewing sarcoma (EWS) are the most common primary bone cancers in children, but acute thrombosis is poorly characterized in this population. Our study evaluated the rates of venous thromboembolism (VTE) and associated risk factors in pediatric patients with bone sarcomas treated over a 10‐year period encompassing
Sarah Kappa, Shou Xu, Mark Zobeck, Sarah E. Sartain, Nino Rainusso, Lisa Wang, Nicole Montgomery, Paige Wheaton, Sarah Whittle   +8 more
wiley   +1 more source

Returnability in complex directed networks (digraphs)

, 2008
The concept of returnability is proposed for complex directed networks (digraphs). It can be seen as a generalization of the concept of reciprocity. Two measures of the returnability are introduced. We establish closed formulas for the calculation of the
Estrada, Ernesto, Estrada, E., Hatano, Naomichi, Hatano, N., Ernesto Estrada, Naomichi Hatano   +5 more
core   +1 more source

Design and directed evolution of noncanonical β-stereoselective metalloglycosidases

Nature Communications, 2022
Metallohydrolases are ubiquitous enzymes. Here the authors show the design and biochemical characterisation of metalloglycosidase by constructing a hydrolytically active Zn-binding site within a barrel-shaped outer membrane protein OmpF.
Woo Jae Jeong, Woon Ju Song
doaj   +1 more source

Serological Benefit of SARS‐CoV‐2 Vaccination Relative to Infection in Children With Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with acute lymphoblastic leukemia (ALL) are at risk of severe outcomes from SARS‐CoV‐2 (SCV2). In the post‐pandemic context, where most children have been infected with SCV2, there are limited data on whether vaccination remains beneficial in children with ALL.
Janna R. Shapiro, Freda Qi, Karen Colwill, Alina D. Dorogy, Ying Liu, Michelle Science, Anne‐Claude Gingras, James M. Rini, Sumit Gupta, Sarah Alexander, Shelly Bolotin, Tania H. Watts   +11 more
wiley   +1 more source

Initial mutations direct alternative pathways of protein evolution

, 2011
Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e.
J Arjan G M de Visser, Tawfik Dan S., Salverda, M.L.M., Merijn L M Salverda, Hoekstra, R.F., Salverda Merijn L. M., Dellus, E., John van der Oost, Alfons J M Debets, Visser, J.A.G.M., de, Gorter Florien A., de Visser J. Arjan G. M., Florien A Gorter, Dellus Eynat, Dan S Tawfik, Gorter, F.A., Debets Alfons J. M., van der Oost John, Eynat Dellus, Hoekstra Rolf F., Debets, A.J.M., Oost, J., van der, J. Arjan G. M. de Visser, Merijn L. M. Salverda, Tawfik, D.S., Florien A. Gorter, Alfons J. M. Debets, Rolf F Hoekstra, de Visser, J.A.G.M., van der Oost, J., Rolf F. Hoekstra, Dan S. Tawfik   +31 more
core   +1 more source

Protein directed evolution

Revista de Química, 2008
Directed evolution allows us to explore protein functionalities not required in the natural environment. It mimics natural genetic processes and selective pressures. This approach is used when the molecular basis is not completely understood and rational
Roberto Laos
doaj  

Claudin‐6 Protein Expression in Atypical Teratoid/Rhabdoid Tumors Is Strongly Enriched in the Molecular Subgroup AT/RT‐TYR

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Claudin‐6 has emerged as a promising immunotherapeutic target, yet protein‐level data in atypical teratoid/rhabdoid tumors (AT/RTs) have been inconsistent. We analyzed 36 well‐characterized AT/RT samples and found membranous claudin‐6 protein expression in 58% of cases, with striking enrichment in the molecular subgroup AT/RT‐TYR (100%) and ...
Victoria E. Fincke, Christian Thomas, Michael C. Frühwald, Pascal D. Johann, Martin Hasselblatt   +4 more
wiley   +1 more source