Results 41 to 50 of about 286,859 (297)

A New Evolution Model for Weighted Directed Networks

Xibei Gongye Daxue Xuebao, 2020
The most of the recent models of directed weighted network evolution capture the growth process based on two conventional assumptions: constant average degree assumption and slowly growing diameter assumption.

doaj   +1 more source

Directed Evolution of Enzymes

, 2010
By controlling the evolution of organisms, humans have been ‘directing’ evolution for thousands of years and the results are easy to see – the everyday domestic dog, for example. People have bred dogs for a number of purposes. This has been accomplished in an iterative process; dogs that displayed desirable traits were bred, their best progeny were ...
Jackson, Colin J., Gillam, Elizabeth M. J., Ollis, David L.   +2 more
openaire   +5 more sources

Quantifying the Performance of Micro-Compartmentalized Directed Evolution Protocols

Life, 2020
High-throughput, in vitro approaches for the evolution of enzymes rely on a random micro-encapsulation to link phenotypes to genotypes, followed by screening or selection steps.
Adèle Dramé-Maigné, Anton S. Zadorin, Iaroslava Golovkova, Yannick Rondelez   +3 more
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Directing Drug Evolution [PDF]

BioTechniques, 2017
Directed evolution is poised to change small molecule discovery and provide greater access to “drug space.” Sarah Webb looks into the evolving drug discovery landscape.
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Towards the Directed Evolution of Hybrid Catalysts

CHIMIA, 2002
The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and ...
Manfred T. Reetz, Martin Rentzsch, Andreas Pletsch, Matthias Maywald   +3 more
doaj   +1 more source

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Behavioral Phylogenies and the Direction of Evolution

Science, 1983
A model for using mate preference data to deduce the direction of evolution between populations related by founder events or population bottlenecks is examined. Data from a wide range of organisms satisfying the necessary constraints of population structure are compatible with the model developed by K. Y. Kaneshiro from studies of Hawaiian
L V, Giddings, A R, Templeton
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European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Directed evolution by in vitro compartmentalization

Nature Methods, 2006
The goal of in vitro compartmentalization (IVC) is to divide a large reaction between many microscopic compartments. This technique was first developed to generate 'artificial cells' for the directed evolution of proteins (Fig. 1). Typically, an aqueous solution of genes and an in vitro transcription-translation system is stirred (or homogenized) into ...
Miller, Oliver, Bernath, Kalia, Agresti, Jeremy, Amitai, Gil, Kelly, Bernard, Mastrobattista, Enrico, Taly, Valérie, Magdassi, Shlomo, Tawfik, Dan, Griffiths, Andrew   +9 more
openaire   +5 more sources

Clinical and Biological Features of Response in Resistant Neuroblastoma to 131I‐Metaiodobenzylguanidine Radiotherapy in the Anti‐GD2 Immunotherapy Era

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman, Katherine K. Matthay, Fabienne Hollinger, Catriona Black, Ann A. Lazar, Miguel Pampaloni, Steven G. DuBois, Kieuhoa T. Vo   +7 more
wiley   +1 more source