Results 41 to 50 of about 1,378,774 (287)
Towards the Directed Evolution of Hybrid Catalysts
CHIMIA, 2002 The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and ...
Manfred T. Reetz +3 more
doaj +1 more source
Machine learning-guided directed evolution for protein engineering [PDF]
, 2019 Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H. +2 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Directed cycles and related structures in random graphs: II--Dynamic properties
, 2003 We study directed random graphs (random graphs whose edges are directed) as they evolve in discrete time by the addition of nodes and edges. For two distinct evolution strategies, one that forces the graph to a condition of near acyclicity at all times ...
Albert +8 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Oral mucositis is a common and debilitating side effect of childhood cancer and stem cell transplant treatments. It affects the quality of life of children and young people (CYP) and places a strain on services. Photobiomodulation is recommended for oral mucositis prevention in international guidance but is poorly implemented in UK ...
Claudia Heggie +4 more
wiley +1 more source
Programming temporal morphing of self-actuated shells [PDF]
, 2020 Advances in shape-morphing materials, such as hydrogels, shape-memory polymers and light-responsive polymers have enabled prescribing self-directed deformations of initially flat geometries.
Bickel, Bernd +4 more
core +4 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background An international Delphi panel of experts developed consensus statements to delineate the circumstances where the risks of dexamethasone as an antiemetic do and do not outweigh its benefits. Procedure Experts in supportive care of pediatric patients were invited to participate.
Negar Shavandi +20 more
wiley +1 more source
Directed Chemical Evolution with an Outsized Genetic Code. [PDF]
PLoS ONE, 2016 The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark +3 more
doaj +1 more source
A C35 Carotenoid Biosynthetic Pathway [PDF]
, 2003 Upon coexpression with Erwinia geranylgeranyldiphosphate (GGDP) synthase in Escherichia coli, C30 carotenoid synthase CrtM from Staphylococcus aureus produces novel carotenoids with the asymmetrical C35 backbone.
Arnold, Frances H., Umeno, Daisuke
core
Directed Percolation Universality in Asynchronous Evolution of Spatio-Temporal Intermittency
, 1997 We present strong evidence that a coupled-map-lattice model for spatio-temporal intermittency belongs to the universality class of directed percolation when the updating rules are asynchronous, i.e.
Bohr, Tomas +2 more
core +2 more sources