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Cybernetics and Directed Evolution
Кібернетика та комп'ютерні технології, 2023 Results. The place and role of cybernetics methods for solving the global problem of directed evolution are considered. The author investigates the eventual phenomenon of the interaction of two coryphaei of Ukrainian science V.I.
Oleksandr Palagin
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, 2021 This book on self-directed learning (SDL) is devoted to original academic scholarship within the field of education, and is the 6th volume in the North-West University (NWU) SDL book series. In this book the authors explore how self-directed learning can
Mzuza, Maureen K. +18 more
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Directed Evolution Methods for Enzyme Engineering
Molecules, 2021 Enzymes underpin the processes required for most biotransformations. However, natural enzymes are often not optimal for biotechnological uses and must be engineered for improved activity, specificity and stability.
Saurabh Rajendra Nirantar
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EnzyHTP Computational Directed Evolution with Adaptive Resource Allocation [PDF]
, 2023 Directed evolution facilitates enzyme engineering via iterative rounds of mutagenesis. Despite the wide applications of high-throughput screening, building “smart libraries” to effectively identify beneficial variants remains a major challenge in the ...
Zhongyue, Yang +2 more
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Hot spots-making directed evolution easier.
Biotechnology Advances, 2022 Directed evolution has emerged as a powerful strategy to engineer various properties of proteins. Traditional methods to construct libraries such as error-prone PCR and DNA shuffling commonly produce large, relatively inefficient libraries.
Hao-Ran Yu +3 more
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Advances in machine learning for directed evolution.
Current Opinion in Structural Biology, 2021 Machine learning (ML) can expedite directed evolution by allowing researchers to move expensive experimental screens in silico. Gathering sequence-function data for training ML models, however, can still be costly.
Bruce J. Wittmann +3 more
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RNA-mediated in vivo Directed Evolution in Yeast
Bio-Protocol, 2022 Directed evolution is a powerful approach to obtain genetically-encoded sought-for traits. Compared to the prolonged adaptation regimes to mutations occurring under natural selection, directed evolution unlocks rapid screening and selection of mutants ...
Emil Jensen, Michael Jensen
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Accounts of Chemical Research, 2021 Conspectus Despite the astonishing diversity of naturally occurring biocatalytic processes, enzymes do not catalyze many of the transformations favored by synthetic chemists.
Yang Yang, F. Arnold
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Designing better enzymes: Insights from directed evolution.
Current Opinion in Structural Biology, 2021 De novo enzymes can be created by computational design and directed evolution. Here, we review recent insights into the origins of catalytic power in evolved designer enzymes to pinpoint opportunities for next-generation designs: Evolution precisely ...
H. Bunzel +2 more
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Models for the directed evolution of bacterial allelopathy: bacteriophage lysins [PDF]
PeerJ, 2015 Microbes produce a variety of compounds that are used to kill or suppress other species. Traditional antibiotics have their origins in these natural products, as do many types of compounds being pursued today in the quest for new antibacterial drugs ...
James J. Bull +3 more
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