Results 21 to 30 of about 269,742 (193)
PAIDDE: A Permutation-Archive Information Directed Differential Evolution Algorithm
IEEE Access, 2022 Evolutionary algorithms have shown great successes in various real-world applications ranging in molecule to astronomy. As a mainstream evolutionary algorithm, differential evolution (DE) possesses the characteristics of simple algorithmic structure ...
Xiaosi Li +5 more
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A New Evolution Model for Weighted Directed Networks
Xibei Gongye Daxue Xuebao, 2020 The most of the recent models of directed weighted network evolution capture the growth process based on two conventional assumptions: constant average degree assumption and slowly growing diameter assumption.
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Quantifying the Performance of Micro-Compartmentalized Directed Evolution Protocols
Life, 2020 High-throughput, in vitro approaches for the evolution of enzymes rely on a random micro-encapsulation to link phenotypes to genotypes, followed by screening or selection steps.
Adèle Dramé-Maigné +3 more
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Directed evolution strategies for improved enzymatic performance
Microbial Cell Factories, 2005 The engineering of enzymes with altered activity, specificity and stability, using directed evolution techniques that mimic evolution on a laboratory timescale, is now well established.
Dalby Paul A, Hibbert Edward G
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Directed Chemical Evolution with an Outsized Genetic Code. [PDF]
PLoS ONE, 2016 The first demonstration that macromolecules could be evolved in a test tube was reported twenty-five years ago. That breakthrough meant that billions of years of chance discovery and refinement could be compressed into a few weeks, and provided a ...
Casey J Krusemark +3 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
wiley +1 more source
Towards the Directed Evolution of Hybrid Catalysts
CHIMIA, 2002 The first step in applying the recently proposed concept concerning the application of directed evolution to the creation of selective hybrid catalysts is described, specifically the covalent attachment of Mn-salen moieties and of Cu-, Pd-, and ...
Manfred T. Reetz +3 more
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Design and directed evolution of noncanonical β-stereoselective metalloglycosidases
Nature Communications, 2022 Metallohydrolases are ubiquitous enzymes. Here the authors show the design and biochemical characterisation of metalloglycosidase by constructing a hydrolytically active Zn-binding site within a barrel-shaped outer membrane protein OmpF.
Woo Jae Jeong, Woon Ju Song
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan +3 more
wiley +1 more source