Results 11 to 20 of about 286,859 (297)
Directed evolution strategies for improved enzymatic performance
Microbial Cell Factories, 2005 The engineering of enzymes with altered activity, specificity and stability, using directed evolution techniques that mimic evolution on a laboratory timescale, is now well established.
Dalby Paul A, Hibbert Edward G
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A risk based assessment approach for chemical mixtures from wastewater treatment plant effluents
Environment International, 2022 In this study, 56 effluent samples from 52 European wastewater treatment plants (WWTPs) were investigated for the occurrence of 499 emerging chemicals (ECs) and their associated potential risks to the environment.
Saskia Finckh +11 more
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Cybernetics and Directed Evolution
Кібернетика та комп'ютерні технології, 2023 Results. The place and role of cybernetics methods for solving the global problem of directed evolution are considered. The author investigates the eventual phenomenon of the interaction of two coryphaei of Ukrainian science V.I.
Oleksandr Palagin
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Directed Evolution Methods for Enzyme Engineering
Molecules, 2021 Enzymes underpin the processes required for most biotransformations. However, natural enzymes are often not optimal for biotechnological uses and must be engineered for improved activity, specificity and stability.
Saurabh Rajendra Nirantar
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Directed polymerase evolution [PDF]
FEBS Letters, 2013 Polymerases evolved in nature to synthesize DNA and RNA, and they underlie the storage and flow of genetic information in all cells. The availability of these enzymes for use at the bench has driven a revolution in biotechnology and medicinal research; however, polymerases did not evolve to function efficiently under the conditions required for some ...
Chen, Tingjian, Romesberg, Floyd E.
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RNA-mediated in vivo Directed Evolution in Yeast
Bio-Protocol, 2022 Directed evolution is a powerful approach to obtain genetically-encoded sought-for traits. Compared to the prolonged adaptation regimes to mutations occurring under natural selection, directed evolution unlocks rapid screening and selection of mutants ...
Emil Jensen, Michael Jensen
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Models for the directed evolution of bacterial allelopathy: bacteriophage lysins [PDF]
PeerJ, 2015 Microbes produce a variety of compounds that are used to kill or suppress other species. Traditional antibiotics have their origins in these natural products, as do many types of compounds being pursued today in the quest for new antibacterial drugs ...
James J. Bull +3 more
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Computationally Optimizing the Directed Evolution of Proteins [PDF]
, 2003 Directed evolution has proven a successful strategy for protein engineering. To accelerate the discovery process, we have developed several computational methods to optimize the mutant libraries by targeting specific residues for mutagenesis, and ...
Voigt, Christopher Ashby
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Parent-Offspring Conflict and the Evolution of Infant-Directed Song
, 2022 We present a theory of the origin and evolution of infant-directed song, a form of music found in many cultures. After examining the ancestral ecology of parent-infant relations, we propose that infant-directed song arose in an evolutionary arms race ...
Mehr, Samuel, Krasnow, Max
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Towards the Directed Evolution of Artificial Metalloenzymes
CHIMIA, 2021 Artificial metalloenzymes (ArMs) are a class of enzymes holding great promise. In contrast to natural enzymes, the core of ArMs is a synthetic metallocofactor, with potential for bio-orthogonal reactivity, incorporated within a host protein.
Jaicy Vallapurackel
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