Results 11 to 20 of about 1,378,774 (287)
Directed Evolution of a Mycobacteriophage [PDF]
Antibiotics, 2019 Bacteriophages represent an alternative strategy to combat pathogenic bacteria. Currently, Mycobacterium tuberculosis infections constitute a major public health problem due to extensive antibiotic resistance in some strains.
María Cebriá-Mendoza +2 more
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Revista de Química, 2008 Directed evolution allows us to explore protein functionalities not required in the natural environment. It mimics natural genetic processes and selective pressures. This approach is used when the molecular basis is not completely understood and rational
Roberto Laos
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Nature, 2021 Abstract Directed evolution can rapidly achieve dramatic improvements in the properties of a protein or bestow entirely new functions on it. We have discovered a strong correlation between the probability of finding a productive mutation at a particular position of a protein and a chemical shift perturbation in Nuclear Magnetic Resonance ...
Sagar Bhattacharya +10 more
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Directed polymerase evolution [PDF]
FEBS Letters, 2013 Polymerases evolved in nature to synthesize DNA and RNA, and they underlie the storage and flow of genetic information in all cells. The availability of these enzymes for use at the bench has driven a revolution in biotechnology and medicinal research; however, polymerases did not evolve to function efficiently under the conditions required for some ...
Chen, Tingjian, Romesberg, Floyd E.
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Towards the Directed Evolution of Artificial Metalloenzymes
CHIMIA, 2021 Artificial metalloenzymes (ArMs) are a class of enzymes holding great promise. In contrast to natural enzymes, the core of ArMs is a synthetic metallocofactor, with potential for bio-orthogonal reactivity, incorporated within a host protein.
Jaicy Vallapurackel
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Synthetic Gene Circuits: Design with Directed Evolution [PDF]
, 2007 Synthetic circuits offer great promise for generating insights into nature's underlying design principles or forward engineering novel biotechnology applications. However, construction of these circuits is not straightforward.
Arnold, Frances H., Haseltine, Eric L.
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Directing Drug Evolution [PDF]
BioTechniques, 2017 Directed evolution is poised to change small molecule discovery and provide greater access to “drug space.” Sarah Webb looks into the evolving drug discovery landscape.
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Directed evolution: selection of the host organism
Computational and Structural Biotechnology Journal, 2012 Directed evolution has become a well-established tool for improving proteins and biological systems. A critical aspect of directed evolution is the selection of a suitable host organism for achieving functional expression of the target gene.
Azadeh Pourmir, Tyler W Johannes
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Evolution of a Student Directed Free Clinic
Journal of Regional Medical Campuses, 2023 This report summarizes the 20 year evolution of community engagement at a small regional rural campus. The process includes establishing a student directed free clinic and its transition through the wider availability of Medicaid expansion.
William J. Crump +3 more
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Emergent spatial structures in critical sandpiles [PDF]
, 1997 We introduce and study a new directed sandpile model with threshold dynamics and stochastic toppling rules. We show that particle conservation law and the directed percolation-like local evolution of avalanches lead to the formation of a spatial ...
Dhar, Deepak, Tadić, Bosiljka
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