Results 61 to 70 of about 11,830,288 (332)

PAIDDE: A Permutation-Archive Information Directed Differential Evolution Algorithm

IEEE Access, 2022
Evolutionary algorithms have shown great successes in various real-world applications ranging in molecule to astronomy. As a mainstream evolutionary algorithm, differential evolution (DE) possesses the characteristics of simple algorithmic structure ...
Xiaosi Li, Kaiyu Wang, Haichuan Yang, Sichen Tao, Shuai Feng, Shangce Gao   +5 more
doaj   +1 more source

Directed Evolution of Fungal Laccases [PDF]

Current Genomics, 2011
Fungal laccases are generalists biocatalysts with potential applications that range from bioremediation to novel green processes. Fuelled by molecular oxygen, these enzymes can act on dozens of molecules of different chemical nature, and with the help of redox mediators, their spectrum of oxidizable substrates is further pushed towards xenobiotic ...
Maté, Diana M., García-Ruiz, Eva, Camarero, Susana, Alcalde Galeote, Miguel   +3 more
openaire   +3 more sources

Deep sequencing revealed molecular signature of horizontal gene transfer of plant like transcripts in the mosquito Anopheles culicifacies: an evolutionary puzzle [version 1; referees: 2 approved]

F1000Research, 2015
In prokaryotes, horizontal gene transfer (HGT) has been regarded as an important evolutionary drive to acquire and retain beneficial genes for their survival in diverse ecologies.
Punita Sharma, Tanwee Das De, Swati Sharma, Ashwani Kumar Mishra, Tina Thomas, Sonia Verma, Vandana Kumari, Suman Lata, Namita Singh, Neena Valecha, Kailash Chand Pandey, Rajnikant Dixit   +11 more
doaj   +1 more source

Directed evolution of engineered virus-like particles with improved production and transduction efficiencies

Nature Biotechnology
Engineered virus-like particles (eVLPs) are promising vehicles for transient delivery of proteins and RNAs, including gene editing agents. We report a system for the laboratory evolution of eVLPs that enables the discovery of eVLP variants with improved ...
Aditya Raguram, Mei-Rui An, Paul Z. Chen, David R. Liu   +3 more
semanticscholar   +1 more source

A New Evolution Model for Weighted Directed Networks

Xibei Gongye Daxue Xuebao, 2020
The most of the recent models of directed weighted network evolution capture the growth process based on two conventional assumptions: constant average degree assumption and slowly growing diameter assumption.

doaj   +1 more source

How directed evolution reshapes energy landscapes in enzymes to boost catalysis

Science, 2020
Two steps forward—now look back Whether designed computationally or uncovered in activity screening, enzymes repurposed for biocatalysis rarely start at the peak of proficiency.
R. Otten, R. Padua, H. Bunzel, V. Nguyen, W. Pitsawong, M. Patterson, Shuo Sui, Sarah L. Perry, Aina E. Cohen, D. Hilvert, D. Kern   +10 more
semanticscholar   +1 more source

Self-Directed Learning for the 21st Century

, 2019
This book is devoted to scholarship in the field of self-directed learning in the 21st century, with specific reference to higher education. The target audience of the book includes scholars in the field of self-directed learning and higher education ...
du Toit, Adri, Johnson, David W., Lubbe, Anitia, Golightly, Aubrey, Johnson, Roger T., Olivier, Jako, van Zyl, Sukie, Bergamin, Per B., Kruger, Corné, van der Westhuizen, Christo, Goede, Roelien, Laubscher, Dorothy, Bosch, Chantelle   +12 more
core   +1 more source

Quantifying the Performance of Micro-Compartmentalized Directed Evolution Protocols

Life, 2020
High-throughput, in vitro approaches for the evolution of enzymes rely on a random micro-encapsulation to link phenotypes to genotypes, followed by screening or selection steps.
Adèle Dramé-Maigné, Anton S. Zadorin, Iaroslava Golovkova, Yannick Rondelez   +3 more
doaj   +1 more source

Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico

Nature Communications, 2020
The creation of artificial enzymes is a key objective of computational protein design. Although de novo enzymes have been successfully designed, these exhibit low catalytic efficiencies, requiring directed evolution to improve activity. Here, we use room-
A. Broom, R. V. Rakotoharisoa, M. Thompson, Niayesh Zarifi, Erin Nguyen, Nurzhan Mukhametzhanov, Lin Liu, J. Fraser, R. Chica   +8 more
semanticscholar   +1 more source

Directed Evolution of Enzymes

, 2010
By controlling the evolution of organisms, humans have been ‘directing’ evolution for thousands of years and the results are easy to see – the everyday domestic dog, for example. People have bred dogs for a number of purposes. This has been accomplished in an iterative process; dogs that displayed desirable traits were bred, their best progeny were ...
Jackson, Colin J., Gillam, Elizabeth M. J., Ollis, David L.   +2 more
openaire   +5 more sources