Results 81 to 90 of about 11,830,288 (332)

CLADE 2.0: Evolution-Driven Cluster Learning-Assisted Directed Evolution

, 2022
Directed evolution, a revolutionary biotechnology in protein engineering, optimizes protein fitness by searching an astronomical mutational space via expensive experiments. The cluster learning-assisted directed evolution (CLADE) efficiently explores the
Guo-Wei Wei (4242466), Yuchi Qiu (11015151)   +1 more
core   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Oncolytic Viruses: The Power of Directed Evolution

Advances in Virology, 2012
Attempts at developing oncolytic viruses have been primarily based on rational design. However, this approach has been met with limited success. An alternative approach employs directed evolution as a means of producing highly selective and potent ...
Maxine Bauzon, Terry W. Hermiston
doaj   +1 more source

Pore evolution mechanisms during directed energy deposition additive manufacturing

Nature Communications
Porosity in directed energy deposition (DED) deteriorates mechanical performances of components, limiting safety-critical applications. However, how pores arise and evolve in DED remains unclear. Here, we reveal pore evolution mechanisms during DED using
Kai Zhang, Yun-Hui Chen, S. Marussi, Xian-Qiang Fan, Maureen Fitzpatrick, S. Bhagavath, Marta Majkut, B. Lukić, Kudakwashe Jakata, A. Rack, Martyn A. Jones, J. Shinjo, C. Panwisawas, C. L. Leung, P. Lee   +14 more
semanticscholar   +1 more source

Blended learning environments to foster self-directed learning [PDF]

, 2022
This book on blended learning environments to foster self-directed learning highlights the focus on research conducted in several teaching and learning contexts where blended learning had been implemented and focused on the fostering of self-directed ...
Ngwenya, Emmanuel, Lotz, Celizma, Olivier, Jako, Werlen, Egon, Bergamin, Per B., Kruger, Corné, Kruger, Donnavan, van Deventer, Nicolaas, Mahlaba, Sfiso Cebolenkosi, Bergamin, Nicole, Mabiletja, Matome Meriam, Jagals, Divan, Dhlamini, Joyce Phikisile, Breed, Betty, Bunt, Byron J., Mirata, Victoria, Kemp, ALbert   +16 more
core   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Generation of enhanced gene delivery vectors by directed evolution of adeno-associated virus [PDF]

, 2006
Despite promising advance in the development of viral vectors based on AAV for human gene therapy, several major hurdles for a more general use remain.
Endell, Jan
core   +1 more source

Protein directed evolution

Revista de Química, 2008
Directed evolution allows us to explore protein functionalities not required in the natural environment. It mimics natural genetic processes and selective pressures. This approach is used when the molecular basis is not completely understood and rational
Roberto Laos
doaj  

Directed evolution by in vitro compartmentalization

Nature Methods, 2006
The goal of in vitro compartmentalization (IVC) is to divide a large reaction between many microscopic compartments. This technique was first developed to generate 'artificial cells' for the directed evolution of proteins (Fig. 1). Typically, an aqueous solution of genes and an in vitro transcription-translation system is stirred (or homogenized) into ...
Miller, Oliver J., Bernath, Kalia, Agresti, Jeremy, Amitai, Gil, Kelly, Bernard, Mastrobattista, Enrico, Taly, Valérie, Magdassi, Shlomo, Tawfik, Dan, Griffiths, Andrew   +9 more
openaire   +5 more sources