Results 91 to 100 of about 1,437,233 (261)
A COMBINATORIAL PROBLEM ON A DIRECTED GRAPH
Revista de Matemática: Teoría y Aplicaciones, 2016 We consider two options for a particle’s entire journey through a certaindirectedgraph. Both options involve a random assignment to the journey route to be followed. We are interested in the option that offers, on average, the shortest route.
Osvaldo Marrero, Paul C. Pasles
doaj +1 more source
Demonstration of a Preprocessor for the Spring Embedder [PDF]
, 2002 Spring embedding is a widely used method for producing automated layouts of graphs. We present a preprocessor that improves the performance of the classical spring embedder which can be used in conjunction with other optimization and approximation ...
Rodgers, Peter +3 more
core +1 more source
DFGraph: A directed and flexible graph library
, 2021 DFGraph is a directed and flexible graph library.
Willi Zschiebsch
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Action planning for graph transition systems [PDF]
, 2005 Graphs are suitable modeling formalisms for software and hardware systems involving aspects such as communication, object orientation, concurrency, mobility and distribution.
Lluch-Lafuente, Alberto +5 more
core +1 more source
The estimated directed graph for “2007-1Q”.
, 2017 The estimated directed graph for “2007-1Q”.
Shotaro Akaho (3633199) +3 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source