Results 91 to 100 of about 208,933 (266)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Reconstruction of graph signals from traffic data on directed road networks using kernel methods

Applied Network Science
The completeness of traffic data sets is endangered by distinct reasons, such as implementation costs or privacy concerns. Modelling an urban network as a road graph (i.e., with roads as nodes, and edges representing intersections) allows the use of ...
Rafael Alejandro Martínez Márquez, Giuseppe Patanè   +1 more
doaj   +1 more source

On the Upward Planarity of Mixed Plane Graphs

Journal of Graph Algorithms and Applications, 2014
A mixed plane graph is a plane graph whose edge set is partitioned into a set of directed edges and a set of undirected edges. An orientation of a mixed plane graph G is an assignment of directions to the undirected edges of G resulting in a directed ...
Fabrizio Frati, Michael Kaufmann, János Pach, Csaba Tóth, David Wood   +4 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Measuring the complexity of directed graphs: A polynomial-based approach.

PLoS ONE, 2019
In this paper, we define novel graph measures for directed networks. The measures are based on graph polynomials utilizing the out- and in-degrees of directed graphs. Based on these polynomial, we define another polynomial and use their positive zeros as
Matthias Dehmer, Zengqiang Chen, Frank Emmert-Streib, Shailesh Tripathi, Abbe Mowshowitz, Alexei Levitchi, Lihua Feng, Yongtang Shi, Jin Tao   +8 more
doaj   +1 more source

DiVenn: An Interactive and Integrated Web-Based Visualization Tool for Comparing Gene Lists

Frontiers in Genetics, 2019
Gene expression data generated from multiple biological samples (mutant, double mutant, and wild-type) are often compared via Venn diagram tools. It is of great interest to know the expression pattern between overlapping genes and their associated gene ...
Liang Sun, Sufen Dong, Sufen Dong, Yinbing Ge, Jose Pedro Fonseca, Zachary T. Robinson, Kirankumar S. Mysore, Perdeep Mehta   +7 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Tr-Span of Directed Wheel Graphs

Discussiones Mathematicae Graph Theory, 2018
In this paper, we consider T-colorings of directed graphs. In particular, we consider as a T-set the set Tr = {0, 1, 2, . . ., r−1, r+1, . . .}. Exact values and bounds of the Tr-span of directed graphs whose underlying graph is a wheel graph are ...
Besson Marc, Tesman Barry
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source