Results 81 to 90 of about 208,933 (266)
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Determinantal properties of Boolean graphs using recursive approach
AKCE International Journal of Graphs and CombinatoricsThe aim of this paper is to study the determinant and inverse of the adjacency matrices of weighted and directed versions of Boolean graphs. Our approach is recursive. We describe the adjacency matrix of a weighted Boolean graph in terms of the adjacency
Gahininath Sonawane +2 more
doaj +1 more source
Interleaved adjoints of directed graphs
European Journal of Combinatorics, 2011 For an integer k >= 1, the k-th interlacing adjoint of a digraph G is the digraph i_k(G) with vertex-set V(G)^k, and arcs ((u_1, ..., u_k), (v_1, ..., v_k)) such that (u_i,v_i) \in A(G) for i = 1, ..., k and (v_i, u_{i+1}) \in A(G) for i = 1, ..., k-1.
Jan Foniok +2 more
openaire +4 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Algorithms for finding the minimum cycle mean in the weighted directed graph [PDF]
Computer Science Journal of Moldova, 1998 In this paper we study the problem of finding the minimum cycle mean in the weighted directed graph. The computational aspect of some algorithms for solving this problem is discussed and two algorithms for minimum cycle mean finding in the weighted ...
D. Lozovanu, C. Petic
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The storage capacity of a directed graph and nodewise autonomous, ubiquitous learning. [PDF]
Front Comput Neurosci, 2023 Wei H, Li F.
europepmc +1 more source
On Making Directed Graphs Transitive
Journal of Computer and System Sciences, 2009 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Mathias Weller +3 more
openaire +1 more source