Results 81 to 90 of about 1,437,233 (261)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The direct expansion of graphs
Discrete Mathematics, 2002 Expansion procedures introduced by \textit{H. M. Mulder} [The expansion procedure for graphs, in: Contemporary methods in graph theory. In honour of Prof. Dr. K. Wagner, 459-477 (1990; Zbl 0744.05064)] proved to be useful in recognition of median, quasi-median and partial Hamming graphs.
openaire +3 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Representing Space: A Hybrid Genetic Algorithm for Aesthetic Graph Layout [PDF]
, 1998 This paper describes a hybrid Genetic Algorithm (GA) that is used to improve the layout of a graph according to a number of aesthetic criteria.
Rodgers, Peter, Hobbs, M.H.W.
core
Directed acyclic graph describing the hypothesized relationships.
, 2012 Directed acyclic graph describing the hypothesized relationships.
Mark Daniel (173278) +13 more
core +1 more source
The diameter of directed graphs
Journal of Combinatorial Theory, Series B, 2005 Let \(D\) be a strongly connected Eulerian oriented graph with \(n\) vertices and minimum out-degree \(\delta\). The author shows that the diameter of \(D\) is at most \(4n/(2\delta+ 1)+ 2\). This bound, which strengthens an earlier bound by \textit{A. V. Knyazev} [Mat.
openaire +2 more sources
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
DIGRUNDY NUMBER OF DIRECTED STAR, BANANA TREE, FIREWORKS, AND COCONUT TREE GRAPHS
BarekengA digrundy coloring of a graph is a vertex coloring in which every vertex assigned a higher color is adjacent to vertices assigned all smaller colors. The maximum number of colors that can be realized in such a coloring of an acyclic directed graph is ...
Raventino Raventino, Fransiskus Fran
doaj +1 more source