Results 51 to 60 of about 139,638 (260)

Identification of critical connectors in the directed reaction-centric graphs of microbial metabolic networks

BMC Bioinformatics, 2019
Background Detection of central nodes in asymmetrically directed biological networks depends on centrality metrics quantifying individual nodes’ importance in a network.
Eun-Youn Kim, Daniel Ashlock, Sung Ho Yoon   +2 more
doaj   +1 more source

Convert a Strongly Connected Directed Graph to a Black-and-White 3-SAT Problem by the Balatonboglár Model

Algorithms, 2020
In a previous paper we defined the black and white SAT problem which has exactly two solutions, where each variable is either true or false. We showed that black and white 2-SAT problems represent strongly connected directed graphs. We presented also the
Gábor Kusper, Csaba Biró
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Directed Acyclic Outerplanar Graphs Have Constant Stack Number [PDF]

TheoretiCS
The stack number of a directed acyclic graph $G$ is the minimum $k$ for which there is a topological ordering of $G$ and a $k$-coloring of the edges such that no two edges of the same color cross, i.e., have alternating endpoints along the topological ...
Paul Jungeblut, Laura Merker, Torsten Ueckerdt   +2 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

On the Graph Isomorphism Completeness of Directed and Multidirected Graphs

Mathematics
The category of directed graphs is isomorphic to a particular category whose objects are labeled undirected bipartite graphs and whose morphisms are undirected graph morphisms that respect the labeling. Based on this isomorphism, we begin by showing that
Sebastian Pardo-Guerra, Vivek Kurien George, Gabriel A. Silva   +2 more
doaj   +1 more source

On Models of Directed Path Graphs Non Rooted Directed Path Graphs [PDF]

Graphs and Combinatorics, 2015
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gutiérrez, Marisa, Tondato, Silvia Beatriz   +1 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Minimum 2-vertex strongly biconnected spanning directed subgraph problem [PDF]

Discrete Mathematics Letters, 2021
Raed Jaberi
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source