Results 231 to 240 of about 489,553 (296)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Molecular basis for the biosynthetic divergence of anthracyclines kosinostatin and chartreusin. [PDF]

Chem Sci
Fang LL, Jia CH, Zhou X, Ma JY, Guo HZ, Ma X, Bai W, Xiang L, Zhu J, Tan RX, Wang YS.   +10 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Editorial: Systemic sclerosis: immunological impacts. [PDF]

Front Immunol
Komura K, Matsushita T.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Advances in molecular and genetic profiling of meningiomas for improved diagnosis, prognosis, and targeted therapy. [PDF]

Front Oncol
Kasi M.
europepmc   +1 more source

Commentary on "detoxification of deoxynivalenol by pathogen-inducible tau-class glutathione transferases from wheat". [PDF]

J Biol Chem
Shendre L.
europepmc   +1 more source

Case Report: Clonal evolution of diffuse large B-cell lymphoma to plasmablastic lymphoma: diagnostic challenges in a case of gastric lesion with EBV-negative PBL. [PDF]

Front Oncol
Xu J, Liu Y, Feng X, Zhao D, Liu K, Cui S, Wang Y.   +6 more
europepmc   +1 more source

Directed evolution of a staphylophage under biofilm and planktonic conditions. [PDF]

NPJ Biofilms Microbiomes
Valdivia C, Domingo-Calap P.
europepmc   +1 more source