Results 241 to 250 of about 493,855 (292)

TMPRSS2:ERG-directed radiosensitization: exploiting DNA repair rewiring in gene fusion-positive prostate cancer. [PDF]

J Clin Invest
Wang X, Chinnaiyan AM.
europepmc   +1 more source

Reprogramming Imine Reductases for Enantioselective Reduction of Electron-Rich Enamides. [PDF]

JACS Au
Liu XQ, Li R, Chen JL, Li Y, Wei L, Wu H, Li L, Chen BH, Wu Y, Liu SJ, Lin GX, Zhang JF, Zheng Y, Zhang C, Yang YF, Wang X, Chen P, Jia ZJ.   +17 more
europepmc   +1 more source

Toward a systems metabolic engineering approach to improve thermotolerance of Escherichia coli. [PDF]

Microb Cell Fact
Pérez-Morales G, Merino E, Cevallos MA, Gosset G, Licona-Cassani C, Caspeta L, Martinez A.   +6 more
europepmc   +1 more source

Dystrophin rescue in the brain for DMD. [PDF]

Mol Ther Nucleic Acids
Li M, Han R.
europepmc   +1 more source

Evolutionary dynamics and molecular adaptation of Rift Valley fever virus across human and non-human outbreaks in Africa

Omara IE, Juma J, Tshiabuila D, Dor G, Wilkinson E, Baxter C, Tegally H, Moir M, Oyola SO, de Oliveira T.   +9 more
europepmc   +1 more source

Directed Evolution in Drops: Molecular Aspects and Applications [PDF]

ACS Synthetic Biology, 2021
The process of optimizing the properties of biological molecules is paramount for many industrial and medical applications. Directed evolution is a powerful technique for modifying and improving biomolecules such as proteins or nucleic acids (DNA or RNA).
Aitor Manteca, Thomas Beneyton, C Axel Innis   +2 more
exaly   +4 more sources

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Directed molecular evolution in plant improvement

Current Opinion in Plant Biology, 2001
Directed molecular evolution is a powerful tool to evolve genes with commercial applications. Its most common application is to evolve enzymes with improved kinetics, altered substrate or product specificities, or improved function in different cellular environments. The technique is beginning to be applied to goals relevant to agriculture.
Michael Lassner
exaly   +3 more sources

Discovery of Superior Enzymes by Directed Molecular Evolution

ChemBioChem, 2001
Natural selection has created optimal catalysts that exhibit their convincing performance even with a number of sometimes counteracting constraints. Optimal performance of enzyme catalysis does not refer necessarily to maximum reaction rate. Rather, it may involve a compromise between specificity, rate, stability, and other chemical constraints ; in ...
Susanne Brakmann
exaly   +5 more sources

Directed Molecular Evolution

Origins of life and evolution of the biosphere, 1999
We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutionary constraints on the DNA sequences themselves, thus retaining these sequences and governing the ...
L F, Harris, M R, Sullivan, D L, Hatfield   +2 more
openaire   +2 more sources

Advances in directed molecular evolution of reporter genes

Critical Reviews in Biotechnology, 2011
Many reporter genes, such as gfp, gusA, and lacZ, are widely used for research into plants, animals, and microorganisms. Reporter genes, which offer high levels of sensitivity and convenience of detection, have been utilized in transgenic technology, promoter analysis, drug screening, and other areas.
Ai-Sheng, Xiong, Ri-He, Peng, Jing, Zhuang, Jim, Davies, Jian, Zhang, Quan-Hong, Yao   +5 more
openaire   +2 more sources