Results 221 to 230 of about 118,573 (345)

Mild Focal Cooling Decouples Dendrites to Reconfigure Cortical Output

Advanced Science, EarlyView.
Mild cooling of the cortical surface selectively modulates apical dendritic excitability, plasticity, and somato‐dendritic coupling, while uncoupling these effects from basal dendrites, and reshapes apical‐driven responses in barrel cortex during whisker touch.
Meisam Habibi Matin, Shulan Xiao, Krishna Jayant   +2 more
wiley   +1 more source

Periostin as a diagnostic marker and therapeutic target for intervertebral disc degeneration. [PDF]

J Orthop Surg Res
Yuan Y, Xu M, Qin T, Sun H, Sun J.
europepmc   +1 more source

An Implanted Tooth That Can Feel

Advanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao, Zhenhua Wu, Jiwei Sun, Ke Song, Jiayi Li, Yujin Li, Wenqi Chen, Hanyu Li, Shue Li, Cheng Yang, Silin Liu, Yunyun Han, Bin Su, Yumei Ding   +13 more
wiley   +1 more source

S100A12 as a Shared Inflammatory Driver of Intervertebral Disc Degeneration and Osteoporosis: A Mendelian Randomization and Experimental Study. [PDF]

J Inflamm Res
Wang Z, Chen B, Liu Z, Zhang Y, Han L.
europepmc   +1 more source

Spinal fusion is associated with increased adjacent segment disc degeneration, without clinical consequence: long-term follow-up of four RCTs

, 2014
Anne F. Mannion, Gunnar Leivseth, JI Brox, Peter Fritzell, Olle Hägg, Jeremy Fairbank   +5 more
openalex   +1 more source

Targeting FABP4 to Inhibit AGEs‐RAGE/NF‐κB Signalling Effectively Ameliorates Nucleus Pulposus Dysfunction and Angiogenesis in Obesity‐Related Intervertebral Disc Degeneration [PDF]

Lin Han, Fudong Li, Huiqiao Wu, Weiheng Wang, Peiwen Chen, Wei Xia, Yang Liu, Kaiqiang Sun, Wenbo Lin   +8 more
openalex   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

HACE1 alleviates intervertebral disc degeneration by inhibiting ferroptosis in nucleus pulposus cells. [PDF]

Sci Rep
Xia J, Zhang W, Jiang Y, Li T, Dong H, Zhu L, Xia Q, Zhao Y, Yi J, Weng Z, Feng S, Xin Z.   +11 more
europepmc   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Immunometabolism: A Novel Therapeutic Target and Its Pharmacological Modulation for Intervertebral Disc Degeneration. [PDF]

Int J Mol Sci
Cheng M, Liu Y, Suo M, Wang K, Chen X, Li Z.   +5 more
europepmc   +1 more source