Results 241 to 250 of about 118,573 (345)

Prevalence of Low Back Pain and Disc Degeneration in Elite Cross‐Country Skiers: A Comparative Study With Non‐Athlete Controls [PDF]

Anni Aavikko, Janne Pesonen, Leena Ristolainen, Niko Murto, Hannu Kautiainen, Teija Lund   +5 more
openalex   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Editorial: Advancing intervertebral disc degeneration research: focus on annulus fibrosus and pain management. [PDF]

Front Sports Act Living
Lu J, Yao L, Wang F, Zu H, Dreyer CH.
europepmc   +1 more source

The protective up-regulation of metallothionein-2A in intervertebral disc degeneration inhibits nucleus pulposus cell ferroptosis through activation of the PI3K/AKT/mTOR pathway

Hao Cai, Huo‐Liang Zheng, Qizhu Chen, Shao-kuan Song, Bing-yi Yang, Yong Wang, Hui Deng, Muradi Mardan, Zeyu Lu, Peng-Bo Chen, Qinqin Xu, Bo Li, Lei‐Sheng Jiang, Xin-Feng Zheng, Sheng‐Dan Jiang   +14 more
openalex   +1 more source

Mendelian randomization analysis identifies HLA‐A and AP2M1 as genetic biomarkers linked to immune–endocytic crosstalk in intervertebral disc degeneration [PDF]

Yukui Tian, Xue Bai, Nianrong Han, Cheng Wang, J Liu   +4 more
openalex   +1 more source

Large‐Scale Genomics Reveals Three‐Source Ancestry and Layered Adaptation to High Altitude in Tibetan Chickens

Advanced Science, EarlyView.
Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao, Ruixue Nie, Hailu Fan, Tenzin Ngodroup, Li Zhu, Hongbin Pan, Bo Zhang, Hao Zhang   +7 more
wiley   +1 more source

Mechanobiology of intervertebral disc degeneration: From pathological mechanisms to therapeutic approaches. [PDF]

Mechanobiol Med
Qiao H, Zhang K, Zhao J.
europepmc   +1 more source

Inflammatory microRNA-194 and -515 attenuate the biosynthesis of chondroitin sulfate during human intervertebral disc degeneration

, 2017
Bo Hu, Chen Xu, Ye Tian, Changgui Shi, Ying Zhang, Lianfu Deng, Hongyu Zhou, Peng Cao, Huajiang Chen, Wen Yuan   +9 more
openalex   +2 more sources

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Circular RNAs in intervertebral disc degeneration: Current insights into mechanisms and therapeutic potentials (Review). [PDF]

Mol Med Rep
Wang L, Yang K, Zhu H, Wang D, Wang F, Du X.   +5 more
europepmc   +1 more source