Results 251 to 260 of about 118,573 (345)

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Proteolytic enzyme models as tunable preclinical platforms for investigating intervertebral disc degeneration. [PDF]

Front Cell Dev Biol
Gewiess J, D'Intino A, Santos A, Alini M, Vernengo AJ.   +4 more
europepmc   +1 more source

What\u27s new in spine surgery [PDF]

, 2003
Anderson, Paul A., Boden, Scott D., Bridwell, Keith H., Vaccaro, Alexander R., Zigler, Jack E.   +4 more
core   +2 more sources

Hsa_circ_0092342 promotes the apoptosis of nucleus pulposus cells by facilitating hsa-miR-320d maturation in intervertebral disc degeneration

Xiaofeng Chen, Qipeng Wei, Qi Li, Weijun Guo, Junxian Xie, Zhen Xiang, Wenxuan Dong, Jianxing Liu, Sihong OuYang, Zhuozheng Deng, Hui Li, Dongling Cai   +11 more
openalex   +1 more source

Mitochondrial Enzymes Mimetic Ultrasmall Palladium Nanozymes Prevent Senescence and Neurodegeneration Through Metabolic Reprogramming

Advanced Science, EarlyView.
Simply constructed polyvinylpyrrolidone (PVP) modified palladium nanoparticles (PdP NPs) as cytochrome c oxidase (CcO) and superoxide dismutase (SOD) mimic are promising multifunctional nanoreactors to boost mitochondrial respiration chain function and refine homeostasis via regulation of mitochondrial dynamics and proteostasis sensor UPRmt, which ...
Wenshu Cong, Haiming Jing, Zinan Li, Wenjing Zhang, Nan Zhang, Yingqiu Xie, Shan Gao, Yuanyu Huang, Junyu Ning   +8 more
wiley   +1 more source

An Implantable Optogenetics‐Engineered Hydrogel for Amelioration of Rheumatoid Arthritis through Light‐Controlled Metabolic Reprogramming of Synovial Macrophages

Advanced Science, EarlyView.
An implantable hydrogel is designed to enable in situ and on‐demand secretion of GLP‐1 in synovium through blue light irradiation to activate GLP‐1R/HK2/VDAC1 pathway for upregulating tricarboxylic acid cycle and oxidative phosphorylation in macrophage, facilitating tissue repair and bone erosion recovery.
Dahai Hu, Yaru Sun, Qi Lu, Yi Zhang, Jieruo Li, Huige Hou, Huajun Wang, Hui Tang, Yunsong Zhang, Xiaofei Zheng, Qingsong Mei   +10 more
wiley   +1 more source

Dual-functional hydrogel platform suppresses M1 activation and stabilizes M2 macrophages in intervertebral disc degeneration. [PDF]

Mater Today Bio
Xu Y, Zhang Z, Chen Z, Xi M, Liu H, Wang K, Xue Y, Li Z, Fang M, Lin Y, Lin F, Zhang N.   +11 more
europepmc   +1 more source

Velutin Inhibits IL‐1β‐Induced Nucleus Pulposus Inflammatory and Extracellular Matrix Degradation Attenuating Mouse Intervertebral Disc Degeneration via the NF‐κB and MAPK Pathways

Yufeng Zhang, Rongjian Xu, Kelei Wang, Xinyu Li, Yun Lou, Li Cao, Wanlei Yang, Yu Qian   +7 more
openalex   +1 more source

INB3P: A Multi‐Modal and Interpretable Co‐Attention Framework Integrating Property‐Aware Explanations and Memory‐Bank Contrastive Fusion for Blood–Brain Barrier Penetrating Peptide Discovery

Advanced Science, EarlyView.
INB3P is a multimodal framework for blood–brain barrier‐penetrating peptide prediction under extreme data scarcity and class imbalance. By combining physicochemical‐guided augmentation, sequence–structure co‐attention, and imbalance‐aware optimization, it improves predictive performance and interpretability.
Jingwei Lv, Qianyang Wu, Jian Liu, Binlu Yang, Yuanhao Li, Junlin Xu, Yajie Meng, Leyi Wei, Zilong Zhang, Quan Zou, Xiulai Li, Feifei Cui   +11 more
wiley   +1 more source

Familial clustering and physiological risk factors associated with intervertebral disc degeneration in a large population-based cohort. [PDF]

Osteoarthr Cartil Open
Rose BJ, Servais M, Aslor C, Christensen GB, Yu Z, Collier D, Crockett DK, Kazmers NH, Jurynec MJ.   +8 more
europepmc   +1 more source