Results 81 to 90 of about 11,790 (293)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The inter and intra-collective circulation of knowledge on experimental activities in professional development and the training of chemistry teacher trainers [PDF]
Investigações em Ensino de Ciências, 2012 This study examined how the professional development and the training of Chemistry teacher trainers can contribute to learning on experimentation in Science/Chemistry teaching.
Fábio Peres Gonçalves +1 more
doaj
Life trajectory of mastectomized women based on the collective subject discourse
, 2016 Objective: to examine the life trajectory of women with mastectomy members of a self-help group. Method: descriptive and exploratory study, with a qualitative approach, using the approach of the oral history of life as a methodological benchmark, meeting the operational phases.
Silva, Marta Batista da +2 more
openaire +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Subjects, Agents, or Collectives? The Discourse of Youth and Philosophy
Legon Journal of the Humanities, 2015 The present paper argues that the term "youth", which is traditionally used to refer both to young people of a certain age bracket and to a time of life between childhood and maturity has acquired distinctive yet contradictory meanings since the 19th century, and that the category of people, individuals, or persons that the concept describes or ...
openaire +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Past and Future in the Construction of Communal Identity: Collective Memory and Mythical Narratives
Skandinaviske Sprogstudier, 2015 This article relates to the question of whether or to what extent identity is wholly constructed through language by engaging in a discussion of how the use of the past enters into the construction of communal identity.
Christoffer Kølvraa
doaj
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source