Results 71 to 80 of about 206,811 (263)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Dimension-corrected discrimination index

Behaviormetrika
Abstract The Discrimination Index ( DI ) or upper-lower index is a simple and robust, classical non-parametric shortcut to evaluate the item discrimination power or item validation in the practical testing settings. Empirical results show that the DI
openaire   +1 more source

Discrimination of chemicals via refractive index by EF-FLRD

Applied Physics B, 2019
Design and application of an evanescent field fiber loop ring-down (EF-FLRD) spectroscopy system for discrimination of chemicals via their refractive indices are presented. To our knowledge, this is the first system that utilizes visible light. The system employs a broadband laser source at 800 nm at 80 MHz whose pulses were selectively picked by a ...
Alim Yolalmaz, Mehmet Fatih Danışman, Okan Esenturk   +2 more
openaire   +2 more sources

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

Assessment of Distractor Functionality in Multiple Choice Questions: Student Generated Versus Teacher Generated Distractors

Medical Journal of Dr. D.Y. Patil Vidyapeeth
Introduction: Distractors for multiple-choice questions can be obtained by various models like expert judgment, software auto-generation, or from student misconception.
J Annie Sheeba, Nilakantan Ananthakrishnan, Charulatha Ravindran, VR Hemanth Kumar   +3 more
doaj   +1 more source

The polytomous discrimination index for prediction involving multistate processes under intermittent observation. [PDF]

Stat Med, 2022
Jiang S, Cook RJ.
europepmc   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Diagnostic Utility of a Revised Formula-based Melanoma Discrimination Index for Nail Streaks in Dermoscopic Practice. [PDF]

Acta Derm Venereol, 2022
Minagawa A, Nakamura A, Koga H, Sota T.
europepmc   +1 more source